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Multistep DNA-templated reactions for the synthesis of functional sequence controlled oligomers
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McKee, Mireya L., Milnes, Phillip J., Bath, J. (Jonathan), Stulz, Eugen, Turberfield, Andrew J. and O'Reilly, Rachel K.. (2010) Multistep DNA-templated reactions for the synthesis of functional sequence controlled oligomers. Angewandte Chemie (International Edition), Vol.49 (No.43). pp. 7948-7951. ISSN 1433-7851
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Official URL: http://dx.doi.org/10.1002/anie.201002721
Abstract
A strand displacement mechanism was designed to permit DNA-templated synthesis of functional oligomers of arbitrary length (see scheme). Key features of the mechanism are that successive coupling reactions take place in near-identical environments and that purification is only necessary in the last synthesis step.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
| Divisions: | Faculty of Science > Chemistry |
| Library of Congress Subject Headings (LCSH): | Biomimetics, Biosynthesis, DNA, Oligomers, Wittig reaction |
| Journal or Publication Title: | Angewandte Chemie (International Edition) |
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA |
| ISSN: | 1433-7851 |
| Official Date: | 2010 |
| Volume: | Vol.49 |
| Number: | No.43 |
| Number of Pages: | 4 |
| Page Range: | pp. 7948-7951 |
| Identification Number: | 10.1002/anie.201002721 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Engineering and Physical Sciences Research Council (EPSRC) |
| Grant number: | EP/F056605/1 (EPSRC), EP/008597/1 (EPSRC) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/4880 |
Data sourced from Thomson Reuters' Web of Knowledge
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