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Multistep DNA-templated reactions for the synthesis of functional sequence controlled oligomers
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McKee, Mireya L., Milnes, Phillip J., Bath, J. (Jonathan), Stulz, Eugen, Turberfield, Andrew J. and O'Reilly, Rachel K. (2010) Multistep DNA-templated reactions for the synthesis of functional sequence controlled oligomers. Angewandte Chemie (International Edition), Vol.49 (No.43). pp. 7948-7951. doi:10.1002/anie.201002721
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Official URL: http://dx.doi.org/10.1002/anie.201002721
Abstract
A strand displacement mechanism was designed to permit DNA-templated synthesis of functional oligomers of arbitrary length (see scheme). Key features of the mechanism are that successive coupling reactions take place in near-identical environments and that purification is only necessary in the last synthesis step.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Biomimetics, Biosynthesis, DNA, Oligomers, Wittig reaction | ||||
| Journal or Publication Title: | Angewandte Chemie (International Edition) | ||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||
| ISSN: | 1433-7851 | ||||
| Official Date: | 2010 | ||||
| Dates: |
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| Volume: | Vol.49 | ||||
| Number: | No.43 | ||||
| Number of Pages: | 4 | ||||
| Page Range: | pp. 7948-7951 | ||||
| DOI: | 10.1002/anie.201002721 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC) | ||||
| Grant number: | EP/F056605/1 (EPSRC), EP/008597/1 (EPSRC) |
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