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Multistep DNA-templated reactions for the synthesis of functional sequence controlled oligomers

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McKee, Mireya L., Milnes, Phillip J., Bath, J. (Jonathan), Stulz, Eugen, Turberfield, Andrew J. and O'Reilly, Rachel K. (2010) Multistep DNA-templated reactions for the synthesis of functional sequence controlled oligomers. Angewandte Chemie (International Edition), Vol.49 (No.43). pp. 7948-7951. doi:10.1002/anie.201002721

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Official URL: http://dx.doi.org/10.1002/anie.201002721

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Abstract

A strand displacement mechanism was designed to permit DNA-templated synthesis of functional oligomers of arbitrary length (see scheme). Key features of the mechanism are that successive coupling reactions take place in near-identical environments and that purification is only necessary in the last synthesis step.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Biomimetics, Biosynthesis, DNA, Oligomers, Wittig reaction
Journal or Publication Title: Angewandte Chemie (International Edition)
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
ISSN: 1433-7851
Official Date: 2010
Dates:
DateEvent
2010Published
Volume: Vol.49
Number: No.43
Number of Pages: 4
Page Range: pp. 7948-7951
DOI: 10.1002/anie.201002721
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Engineering and Physical Sciences Research Council (EPSRC)
Grant number: EP/F056605/1 (EPSRC), EP/008597/1 (EPSRC)

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