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Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium : biological relevance and synthetic strategies
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Barry, Nicolas P. E. and Sadler, P. J.. (2012) Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium : biological relevance and synthetic strategies. Chemical Society Reviews, Vol.41 (No.8). pp. 3264-3279. ISSN 0306-0012
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Official URL: http://dx.doi.org/10.1039/C2CS15300A
Abstract
This review describes how the incorporation of dicarba-closo-dodecarboranes into half-sandwich complexes of ruthenium, osmium, rhodium and iridium might lead to the development of a new class of compounds with applications in medicine. Such a combination not only has unexplored potential in traditional areas such as Boron Neutron Capture Therapy agents, but also as pharmacophores for the targeting of biologically important proteins and the development of targeted drugs. The synthetic pathways used for the syntheses of dicarba-closo-dodecarboranes-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium are also reviewed. Complexes with a wide variety of geometries and characteristics can be prepared. Examples of addition reactions on the metal centre, B–H activation, transmetalation reactions and/or direct formation of metal–metal bonds are discussed (103 references).
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Science > Chemistry |
| Library of Congress Subject Headings (LCSH): | Ruthenium, Osmium, Rhodium, Iridium, Organometallic compounds -- Therapeutic use, Antineoplastic agents -- Development, Metal-metal bonds, Synthesis |
| Journal or Publication Title: | Chemical Society Reviews |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 0306-0012 |
| Date: | 2012 |
| Volume: | Vol.41 |
| Number: | No.8 |
| Page Range: | pp. 3264-3279 |
| Identification Number: | 10.1039/c2cs15300a |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung [Swiss National Science Foundation] (SNSF), European Research Council (ERC) |
| Grant number: | PBNEP2-134393 (SNSF), 247450 (ERC) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/48802 |
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