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Structure and function of Mycobacterium tuberculosis meso-diaminopimelic acid (DAP) biosynthetic enzymes
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Usha, Veeraraghavan, Lloyd, Adrian, Lovering, Andrew L. and Besra, Gurdyal S. (2012) Structure and function of Mycobacterium tuberculosis meso-diaminopimelic acid (DAP) biosynthetic enzymes. FEMS Microbiology Letters, Vol.330 (No.1). pp. 10-16. doi:10.1111/j.1574-6968.2012.02527.x ISSN 0378-1097.
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Official URL: http://dx.doi.org/10.1111/j.1574-6968.2012.02527.x
Abstract
Because of an increased emergence of resistance to current antitubercular drugs, there is a need for new antitubercular agents directed against novel targets. Diaminopimelic acid (DAP) biosynthetic enzymes are unique to bacteria and are absent in mammals and provide a rich source of essential targets for antitubercular chemotherapy. Herein, we review the structure and function of the mycobacterial DAP biosynthetic enzymes.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
| Journal or Publication Title: | FEMS Microbiology Letters | ||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | ||||
| ISSN: | 0378-1097 | ||||
| Official Date: | 2012 | ||||
| Dates: |
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| Volume: | Vol.330 | ||||
| Number: | No.1 | ||||
| Page Range: | pp. 10-16 | ||||
| DOI: | 10.1111/j.1574-6968.2012.02527.x | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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