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Structure and function of Mycobacterium tuberculosis meso-diaminopimelic acid (DAP) biosynthetic enzymes

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Usha, Veeraraghavan, Lloyd, Adrian, Lovering, Andrew L. and Besra, Gurdyal S. (2012) Structure and function of Mycobacterium tuberculosis meso-diaminopimelic acid (DAP) biosynthetic enzymes. FEMS Microbiology Letters, Vol.330 (No.1). pp. 10-16. doi:10.1111/j.1574-6968.2012.02527.x ISSN 0378-1097.

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Official URL: http://dx.doi.org/10.1111/j.1574-6968.2012.02527.x

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Abstract

Because of an increased emergence of resistance to current antitubercular drugs, there is a need for new antitubercular agents directed against novel targets. Diaminopimelic acid (DAP) biosynthetic enzymes are unique to bacteria and are absent in mammals and provide a rich source of essential targets for antitubercular chemotherapy. Herein, we review the structure and function of the mycobacterial DAP biosynthetic enzymes.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Journal or Publication Title: FEMS Microbiology Letters
Publisher: Wiley-Blackwell Publishing Ltd.
ISSN: 0378-1097
Official Date: 2012
Dates:
DateEvent
2012Published
Volume: Vol.330
Number: No.1
Page Range: pp. 10-16
DOI: 10.1111/j.1574-6968.2012.02527.x
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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