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Kinesin backsteps

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Carter, Nicholas J. and Cross, R. A. (2012) Kinesin backsteps. Biochemical Society Transactions, Vol.40 (No.2). pp. 400-403. doi:10.1042/BST20120008 ISSN 0300-5127.

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Official URL: http://dx.doi.org/10.1042/BST20120008

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Abstract

Kinesin-1 is a walking machine that takes ~8 nm steps along microtubules. Some aspects of the molecular mechanism of walking are now clear, but many are not. In the present paper, we discuss currently controversial points, focusing on the pathways by which kinesin takes occasional backsteps. Backsteps represent failures of the forwards-biasing mechanism. By studying the mechanochemistry of backstepping, one can learn much about the underlying molecular mechanisms responsible for forwards directional bias in the walking action.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Biochemical Society Transactions
Publisher: Portland Press Ltd
ISSN: 0300-5127
Official Date: 2012
Dates:
DateEvent
2012Published
Volume: Vol.40
Number: No.2
Page Range: pp. 400-403
DOI: 10.1042/BST20120008
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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