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Kinesin backsteps
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Carter, Nicholas J. and Cross, R. A. (2012) Kinesin backsteps. Biochemical Society Transactions, Vol.40 (No.2). pp. 400-403. doi:10.1042/BST20120008
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Official URL: http://dx.doi.org/10.1042/BST20120008
Abstract
Kinesin-1 is a walking machine that takes ~8 nm steps along microtubules. Some aspects of the molecular mechanism of walking are now clear, but many are not. In the present paper, we discuss currently controversial points, focusing on the pathways by which kinesin takes occasional backsteps. Backsteps represent failures of the forwards-biasing mechanism. By studying the mechanochemistry of backstepping, one can learn much about the underlying molecular mechanisms responsible for forwards directional bias in the walking action.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Biochemical Society Transactions | ||||
| Publisher: | Portland Press Ltd | ||||
| ISSN: | 0300-5127 | ||||
| Official Date: | 2012 | ||||
| Dates: |
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| Volume: | Vol.40 | ||||
| Number: | No.2 | ||||
| Page Range: | pp. 400-403 | ||||
| DOI: | 10.1042/BST20120008 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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