Epiphenomenon of telomere lengths : lessons from ulcerative colitis
Arasaradnam, Ramesh P. and Nwokolo, Chuka U. (2012) Epiphenomenon of telomere lengths : lessons from ulcerative colitis. Gut, Vol.61 (No.10). p. 1516. ISSN 0017-5749
WRAP_Arasaradnam_Letter to the Editor Jan 2012.pdf - Accepted Version
Restricted to Repository staff only until 6 November 2012.
Official URL: http://dx.doi.org/10.1136/gutjnl-2012-302102
We read with great interest the article by Jones et al detailing TERC polymorphisms, longer telomeres and increased risk of colorectal cancer (CRC).1 Indeed, it is accepted that shorter telomere lengths (measured from peripheral leucocytes) have been shown in senescent somatic cells and also to predispose to cancer. The biological rationale is that telomeres which form a protective cap at the end of chromosomes can be disrupted to undergo double strand breaks, inefficient repair and eventually chromosomal instability. The latter is a well-established precursor to cancer development. Thus, the authors' finding of longer telomeres associated with risk of CRC is particularly intriguing.
|Item Type:||Journal Item|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Divisions:||Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI)|
|Library of Congress Subject Headings (LCSH):||Telomere, Ulcerative colitis -- Susceptibility|
|Journal or Publication Title:||Gut|
|Publisher:||B M J Group|
|Page Range:||p. 1516|
|References:||1. Arasaradnam R and Nwokolo C. Ulcerative colitis – Biological determinants in UC. ImTech publications 2011. 2. Usslemann B, Newbold M, Morris AG, Nwokolo C. Deficiency of colonic telomerase in ulcerative colitis. Am J Gastroenterol 2001;96:1106-12. 3. Getliffe K, Martin-Ruiz C, Passos JF, von-Zglinicki, Nwokolo C. Extended lifespan and long telomeres in rectal fibroblasts from late-onset ulcerative colitis patients. Eur J Gastroenterol Hepatol 2006;18(2):133-41 4. Da Silva N, Arasaradnam R, Getliffe K, Sung E, Oo Y, Nwokolo C. Altered mRNA expression of telomere binding proteins (TPP1, POT1, RAP1, TRF1, TRF2) in Ulcerative colitis and Crohn’s disease. Dig Liver Dis 2010; 42(8):544-8|
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