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Organometallic ruthenium and iridium transfer-hydrogenation catalysts using coenzyme NADH as a cofactor
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Betanzos-Lara, Soledad, Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Qamar, Bushra and Sadler, P. J. (2012) Organometallic ruthenium and iridium transfer-hydrogenation catalysts using coenzyme NADH as a cofactor. Angewandte Chemie International Edition, Vol.51 (No.16). pp. 3897-3900. doi:10.1002/anie.201108175 ISSN 1433-7851.
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Official URL: http://dx.doi.org/10.1002/anie.201108175
Abstract
Artificial enzymes: Half-sandwich arene ruthenium(II) and cyclopentadienyl iridium(III) complexes containing N,N-chelated ligands can use NADH as a source of hydride for the reduction of ketones (see picture). Moreover, cyclopentadienyl phenanthroline iridium(III) derivatives at micromolar concentrations are robust catalysts for the production of H2 from NADH in water and can raise the NAD+/NADH ratio in cancer cells.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | Angewandte Chemie International Edition | ||||
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||
ISSN: | 1433-7851 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | Vol.51 | ||||
Number: | No.16 | ||||
Page Range: | pp. 3897-3900 | ||||
DOI: | 10.1002/anie.201108175 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published |
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