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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

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Speliotes, Elizabeth K., Willer, Cristen J., Berndt, Sonja I., Monda, Keri L., Thorleifsson, Gudmar, Jackson, Anne U., Allen, Hana Lango, Lindgren, Cecilia M., Luan, Jian'an, Maegi, Reedik et al.
). (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature Genetics, Vol.42 (No.11). pp. 937-948. ISSN 1061-4036

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Abstract

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Nature Genetics
Publisher: Nature Publishing Group
ISSN: 1061-4036
Date: November 2010
Volume: Vol.42
Number: No.11
Number of Pages: 14
Page Range: pp. 937-948
Identification Number: 10.1038/ng.686
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Academy of Finland, ADA, Amgen, Agency for Science, Technology and Research of Singapore (A<SUP>star</SUP>STAR), ALF/LUA, Althingi (the Icelandic Parliament), AstraZeneca, Augustinus Foundation, Australian National Health and Medical Research Council, Australian Research Council (ARC), Becket Foundation, Biocenter (Finland), Biomedicum Helsinki Foundation, Boston Obesity Nutrition Research Center, British Diabetes Association, British Heart Foundation, Busselton Population Medical Research Foundation, Cambridge Institute for Medical Research, Cambridge National Institute of Health Research (NIHR) Comprehensive Biomedical Research Centre, CamStrad (UK), Cancer Research UK, Centre for Medical Systems Biology (The Netherlands), Centre for Neurogenomics and Cognitive Research (The Netherlands), Chief Scientist Office of the Scottish Government, Contrat Plan Etat Region (France), Danish Centre for Health Technology Assessment, Danish Diabetes Association, Danish Heart Foundation, Danish Pharmaceutical Association, Danish Research Council, Deutsche Forschungsgemeinschaft (DFG), Department of Health (UK), Diabetes UK, Diabetes and Inflammation Laboratory, Donald W. Reynolds Foundation, Dresden University of Technology, Emil and Vera Cornell Foundation, Erasmus Medical Center (Rotterdam), Erasmus University (Rotterdam), European Commission, Federal Ministry of Education and Research (Germany), Federal State of Mecklenburg-West Pomerania, European Social Fund, Eve Appeal, Finnish Diabetes Research Foundation, Finnish Foundation for Cardiovascular Research, Finnish Foundation for Pediatric Research, Finnish Medical Society, Finska Lakaresallskapet, Paivikki and Sakari Sohlberg Foundation, Folkhalsan Research Foundation, Fond Europeen pour le Developpement Regional (France), Fondation LeDucq (Paris, France), Foundation for Life and Health in Finland, Foundation for Strategic Research (Sweden), Genetic Association Information Network, German Research Council, German National Genome Research Net 'NGFNplus', German Research Center for Environmental Health, Giorgi-Cavaglieri Foundation, GlaxoSmithKline, Goteborg Medical Society, Great Wine Estates Auctions, Gyllenberg Foundation, Health Care Centers in Vasa, Narpes and Korsholm, Healthway, Western Australia, Helmholtz Center Munich, Helsinki University Central Hospital, Hjartavernd (the Icelandic Heart Association); INSERM (France), Ib Henriksen Foundation, Interdisziplinares Zentrum fur Klinische Forschung (IZKF), Jalmari and Rauha Ahokas Foundation, Juho Vainio Foundation, Juvenile Diabetes Research Foundation International (JDRF), Karolinska Institute, Knut and Alice Wallenberg Foundation, Leenaards Foundation, Lundbeck Foundation Centre of Applied Medical Genomics for Personalized Disease Prediction, Prevention and Care (LUCAMP), Lundberg Foundation, Marie Curie Intra-European Fellowship, Medical Research Council (UK), Ministry of Cultural Affairs and Social Ministry of the Federal State of Mecklenburg-West Pomerania, Ministry for Health, Welfare and Sports (The Netherlands), Ministry of Education (Finland), Ministry of Education, Culture and Science (The Netherlands), Ministry of Internal Affairs and Health (Denmark), Ministry of Science, Education and Sport of the Republic of Croatia, Ministry of Science, Research and the Arts Baden-Wurttemberg, Montreal Heart Institute Foundation, Municipal Health Care Center and Hospital in Jakobstad, Municipality of Rotterdam, Narpes Health Care Foundation, National Cancer Institute, National Health and Medical Research Council of Australia, National Institute for Health Research Cambridge Biomedical Research Centre, National Institute for Health Research Oxford Biomedical Research Centre
Grant number: 10404, 77299, 104781, 114382, 117797, 120315, 241944, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 496688, 552485, 613672, DP0770096, 1192, 97020, PG/02/128, HE 1446/4-1, QLG1-CT-2000-01643, QLG2-CT-2002-01254, LSHC-CT-2005, LSHG-CT-2006-018947
URI: http://wrap.warwick.ac.uk/id/eprint/4908

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