Evans, N. D., Moyse, H. A. J. , Lowe, D., Briggs, D., Higgins, R., Mitchell, Daniel Anthony, Zehnder, Daniel and Chappell, M. J. (Michael J.). (2013) Structural identifiability of surface binding reactions involving heterogeneous analyte : application to surface plasmon resonance experiments. Automatica, Volume 49 (Number 1). pp. 48-57. ISSN 0005-1098

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Abstract

Binding affinities are useful measures of target interaction and have an important role in understanding biochemical reactions that involve binding mechanisms. Surface plasmon resonance (SPR) provides convenient real-time measurement of the reaction that enables subsequent estimation of the reaction constants necessary to determine binding affinity. Three models are considered for application to SPR experiments—the well mixed Langmuir model and two models that represent the binding reaction in the presence of transport effects. One of these models, the effective rate constant approximation, can be derived from the other by applying a quasi-steady state assumption. Uniqueness of the reaction constants with respect to SPR measurements is considered via a structural identifiability analysis. It is shown that the models are structurally unidentifiable unless the sample concentration is known. The models are also considered for analytes with heterogeneity in the binding kinetics. This heterogeneity further confounds the identifiability of key parameters necessary for reliable estimation of the binding affinity

Item Type:	Journal Article
Subjects:	Q Science > QC Physics Q Science > QD Chemistry
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Science > Engineering Faculty of Science > Molecular Organisation and Assembly in Cells (MOAC)
Library of Congress Subject Headings (LCSH):	Surface plasmon resonance -- Mathematical models, Binding sites (Biochemistry), Surface chemistry
Journal or Publication Title:	Automatica
Publisher:	Pergamon
ISSN:	0005-1098
Date:	January 2013
Volume:	Volume 49
Number:	Number 1
Page Range:	pp. 48-57
Identification Number:	10.1016/j.automatica.2012.09.015
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
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URI:	http://wrap.warwick.ac.uk/id/eprint/49183

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