Smith, C., Ondračková, M., Spence, R., Adams, Sally, Betts, D. S. and Mallon, E.. (2011) Pathogen-mediated selection for MHC variability in wild zebrafish. Evolutionary Ecology Research, Vol.67 (No.4). pp. 217-218. ISSN 1522-0613

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Abstract

Hypothesis: Genes of the major histocompatibility complex (MHC) show high variability, which is believed to arise through pathogen-mediated selection. Organism: Zebrafish (Danio rerio) from seven independent natural populations. Location: Bangladesh: two sites in Khulna District in the River Ganges drainage, and five sites in Mymensingh District in the River Brahmaputra drainage. Methods: We investigated the relationship of parasite abundance and diversity with allelic variability of the MHC class II B gene in natural populations of zebrafish. A sample of 120 zebrafish was screened for metazoan parasites, and a subsample of 77 was assessed for immunogenetic variation. In total, 2475 metazoan parasites from 23 taxa were identified and 13 unique MHC class IIB alleles were isolated. Conclusion: We found no evidence for a heterozygote advantage, and overall there was lower than expected heterozygosity of MHC alleles. We identified lower parasite abundance and diversity with specific MHC alleles, and this pattern varied between geographic regions. Results suggest that MHC variability in zebrafish is maintained by frequency-dependent and fluctuating selection. © 2011 Carl Smith.

Item Type:	Journal Article
Divisions:	Faculty of Science > Life Sciences (2010- )
Journal or Publication Title:	Evolutionary Ecology Research
Publisher:	Evolutionary Ecology Ltd
ISSN:	1522-0613
Date:	September 2011
Volume:	Vol.67
Number:	No.4
Page Range:	pp. 217-218
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/49255

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