Pathogen-mediated selection for MHC variability in wild zebrafish
Smith, C., Ondračková, M., Spence, R., Adams, Sally, Betts, D. S. and Mallon, E.. (2011) Pathogen-mediated selection for MHC variability in wild zebrafish. Evolutionary Ecology Research, Vol.67 (No.4). pp. 217-218. ISSN 1522-0613Full text not available from this repository.
Official URL: http://www.evolutionary-ecology.com
Hypothesis: Genes of the major histocompatibility complex (MHC) show high variability, which is believed to arise through pathogen-mediated selection. Organism: Zebrafish (Danio rerio) from seven independent natural populations. Location: Bangladesh: two sites in Khulna District in the River Ganges drainage, and five sites in Mymensingh District in the River Brahmaputra drainage. Methods: We investigated the relationship of parasite abundance and diversity with allelic variability of the MHC class II B gene in natural populations of zebrafish. A sample of 120 zebrafish was screened for metazoan parasites, and a subsample of 77 was assessed for immunogenetic variation. In total, 2475 metazoan parasites from 23 taxa were identified and 13 unique MHC class IIB alleles were isolated. Conclusion: We found no evidence for a heterozygote advantage, and overall there was lower than expected heterozygosity of MHC alleles. We identified lower parasite abundance and diversity with specific MHC alleles, and this pattern varied between geographic regions. Results suggest that MHC variability in zebrafish is maintained by frequency-dependent and fluctuating selection. © 2011 Carl Smith.
|Item Type:||Journal Article|
|Divisions:||Faculty of Science > Life Sciences (2010- )|
|Journal or Publication Title:||Evolutionary Ecology Research|
|Publisher:||Evolutionary Ecology Ltd|
|Official Date:||September 2011|
|Page Range:||pp. 217-218|
|Access rights to Published version:||Restricted or Subscription Access|
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