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The impact of insulin resistance on woman's health and potential treatment options
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Lois, Konstantinos, Valsamakis, Georgios, Mastorakos, George and Kumar, Sudhesh (2010) The impact of insulin resistance on woman's health and potential treatment options. In: 7th Athens Conference on Womens Health and Disease: Gynecologic, Endocrine, and Reproductive Issues, Athens, Greece, September 11-13, 2008. Published in: Annals of the New York Academy of Sciences, Vol.1205 pp. 156-165. ISBN 978-1-57331-768-9. ISSN 0077-8923. doi:10.1111/j.1749-6632.2010.05646.x
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Official URL: http://dx.doi.org/10.1111/j.1749-6632.2010.05646.x
Abstract
Insulin resistance (IR) is causatively related to metabolic syndrome and type 2 diabetes, both of which increase the risk of adverse cardiovascular events; in women in particular, severe IR affects the reproductive system causing subfertility and health problems to the mother and the fetus. To date lifestyle modification is the mainstay of treatment, whereas antiobesity drugs and bariatric surgery have been shown to improve insulin sensitivity and many surrogate metabolic defects, real reduction in cardiovascular endpoints has yet to be proved. Increasing attention is being directed to the role of the central nervous system in the modulation of IR, as well as to the use of recombinant adipocytokines for IR management. The scope of this article is to cast light on the detrimental effects of IR on metabolism and the body systems in women as well as to highlight the current therapeutic approach, drugs in progress, and future therapeutic perspectives.
| Item Type: | Conference Item (Paper) | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science | ||||
| Divisions: | Faculty of Medicine > Warwick Medical School | ||||
| Series Name: | Annals of the New York Academy of Sciences | ||||
| Journal or Publication Title: | Annals of the New York Academy of Sciences | ||||
| Publisher: | Wiley-Blackwell Publishing, Inc. | ||||
| ISBN: | 978-1-57331-768-9 | ||||
| ISSN: | 0077-8923 | ||||
| Editor: | Creatsas, G and Mastorakos, G | ||||
| Official Date: | September 2010 | ||||
| Dates: |
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| Volume: | Vol.1205 | ||||
| Number of Pages: | 10 | ||||
| Page Range: | pp. 156-165 | ||||
| DOI: | 10.1111/j.1749-6632.2010.05646.x | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | 7th Athens Conference on Womens Health and Disease: Gynecologic, Endocrine, and Reproductive Issues | ||||
| Type of Event: | Conference | ||||
| Location of Event: | Athens, Greece | ||||
| Date(s) of Event: | September 11-13, 2008 |
Data sourced from Thomson Reuters' Web of Knowledge
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