Lois, Konstantinos, Valsamakis, Georgios, Mastorakos, George and Kumar, Sudhesh (2010) The impact of insulin resistance on woman's health and potential treatment options. In: 7th Athens Conference on Womens Health and Disease: Gynecologic, Endocrine, and Reproductive Issues, Athens, Greece, September 11-13, 2008. Published in: Annals of the New York Academy of Sciences, Vol.1205 pp. 156-165.

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Abstract

Insulin resistance (IR) is causatively related to metabolic syndrome and type 2 diabetes, both of which increase the risk of adverse cardiovascular events; in women in particular, severe IR affects the reproductive system causing subfertility and health problems to the mother and the fetus. To date lifestyle modification is the mainstay of treatment, whereas antiobesity drugs and bariatric surgery have been shown to improve insulin sensitivity and many surrogate metabolic defects, real reduction in cardiovascular endpoints has yet to be proved. Increasing attention is being directed to the role of the central nervous system in the modulation of IR, as well as to the use of recombinant adipocytokines for IR management. The scope of this article is to cast light on the detrimental effects of IR on metabolism and the body systems in women as well as to highlight the current therapeutic approach, drugs in progress, and future therapeutic perspectives.

Item Type:	Conference Item (Paper)
Subjects:	Q Science
Divisions:	Faculty of Medicine > Warwick Medical School
Series Name:	Annals of the New York Academy of Sciences
Journal or Publication Title:	Annals of the New York Academy of Sciences
Publisher:	Wiley-Blackwell Publishing, Inc.
ISBN:	978-1-57331-768-9
ISSN:	0077-8923
Editor:	Creatsas, G and Mastorakos, G
Official Date:	September 2010
Volume:	Vol.1205
Number of Pages:	10
Page Range:	pp. 156-165
Identification Number:	10.1111/j.1749-6632.2010.05646.x
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Conference Paper Type:	Paper
Title of Event:	7th Athens Conference on Womens Health and Disease: Gynecologic, Endocrine, and Reproductive Issues
Type of Event:	Conference
Location of Event:	Athens, Greece
Date(s) of Event:	September 11-13, 2008
URI:	http://wrap.warwick.ac.uk/id/eprint/4951

Data sourced from Thomson Reuters' Web of Knowledge

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