Walker, Christopher S., Conner, Alex C., Poyner, David R. and Hay, Debbie L. (2010) Regulation of signal transduction by calcitonin gene-related peptide receptors. Trends in Pharmacological Sciences, Vol.31 (No.10). pp. 476-483. ISSN 0165-6147

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Abstract

Calcitonin gene-related peptide (CGRP) plays a pivotal role in migraine, activating its cognate receptor to initiate intracellular signalling. This atypical receptor comprises a distinct assembly, made up of a G protein-coupled receptor (GPCR), a single transmembrane protein, and an additional protein that is required for Gas coupling. By altering the expression of individual receptor components, it might be possible to adjust cellular sensitivity to CGRP. In recognition of the increasing clinical significance of CGRP receptors, it is timely to review the signalling pathways that might be controlled by this receptor, how the activity of the receptor itself is regulated, and our current understanding of the molecular mechanisms involved in these processes. Like many GPCRs, the CGRP receptor appears to be promiscuous, potentially coupling to several G proteins and intracellular pathways. Their precise composition is likely to be cell type dependent, and much work is needed to ascertain their physiological significance.

Item Type:	Journal Item
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Trends in Pharmacological Sciences
Publisher:	Elsevier Ltd.
ISSN:	0165-6147
Date:	October 2010
Volume:	Vol.31
Number:	No.10
Number of Pages:	8
Page Range:	pp. 476-483
Identification Number:	10.1016/j.tips.2010.06.006
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/4952

Data sourced from Thomson Reuters' Web of Knowledge

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