Regulation of signal transduction by calcitonin gene-related peptide receptors
Walker, Christopher S., Conner, Alex C., Poyner, David R. and Hay, Debbie L. (2010) Regulation of signal transduction by calcitonin gene-related peptide receptors. Trends in Pharmacological Sciences, Vol.31 (No.10). pp. 476-483. ISSN 0165-6147Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.tips.2010.06.006
Calcitonin gene-related peptide (CGRP) plays a pivotal role in migraine, activating its cognate receptor to initiate intracellular signalling. This atypical receptor comprises a distinct assembly, made up of a G protein-coupled receptor (GPCR), a single transmembrane protein, and an additional protein that is required for Gas coupling. By altering the expression of individual receptor components, it might be possible to adjust cellular sensitivity to CGRP. In recognition of the increasing clinical significance of CGRP receptors, it is timely to review the signalling pathways that might be controlled by this receptor, how the activity of the receptor itself is regulated, and our current understanding of the molecular mechanisms involved in these processes. Like many GPCRs, the CGRP receptor appears to be promiscuous, potentially coupling to several G proteins and intracellular pathways. Their precise composition is likely to be cell type dependent, and much work is needed to ascertain their physiological significance.
|Item Type:||Journal Item|
|Subjects:||R Medicine > RS Pharmacy and materia medica|
|Divisions:||Faculty of Medicine > Warwick Medical School|
|Journal or Publication Title:||Trends in Pharmacological Sciences|
|Number of Pages:||8|
|Page Range:||pp. 476-483|
|Access rights to Published version:||Restricted or Subscription Access|
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