Sentinel node status predicts survival in thick melanomas : the Oxford perspective
Rughani, M. G., Swan, M. C., Adams, T. S., Marshall, A. (Andrea), Asher, R., Cassell, O. C. and Middleton, M. (Mark). (2012) Sentinel node status predicts survival in thick melanomas : the Oxford perspective. European Journal of Surgical Oncology (EJSO), Vol.38 (No.10). pp. 936-942. ISSN 0748-7983Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.ejso.2012.04.011
Aims To determine the prognostic value of SLNB in patients with thick melanoma in terms of overall survival (OS) and recurrence-free survival (RFS). Methods 136 patients with primary tumours (Breslow thickness ≥4.0 mm) underwent SLNB. OS and RFS were calculated and a multivariate Cox regression model used to determine the important prognostic factors for predicting OS and RFS. Results Median Breslow thickness was 5.5 mm and 60% were ulcerated. Median follow up was 4 years (95% CI = 4–5) with 54 patients having died at the time of analysis. 5-year OS for SLNB positive patients was 32%, compared to 78% for negative patients. The significant predictors of poorer OS were increasing age (p = 0.03), increasing Breslow thickness (p = 0.03) and SLNB positivity (p < 0.0001). 5 year RFS was significantly worse in the SLNB positive population compared to the negative patients (p < 0.0001); 27% versus 66% respectively. Conclusions Patients with a thick melanoma and a positive SLNB have a significantly worse RFS and OS compared to those with a negative SLNB. Over three-quarters of patients with a negative SLNB survived five years. These findings have implications for the subpopulations included in adjuvant therapy trials and we advocate SLNB be recommended in patients with thick melanomas.
|Item Type:||Journal Article|
|Divisions:||Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||European Journal of Surgical Oncology (EJSO)|
|Publisher:||W.B. Saunders Co. Ltd.|
|Page Range:||pp. 936-942|
|Access rights to Published version:||Restricted or Subscription Access|
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