Talib, Marina (2012) Fabrication and characterisation of 3 dimensional scaffold for tissue engineering application via microstereolithography technique. PhD thesis, University of Warwick.

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Abstract

Microstereolithography is a method used for rapid prototyping of polymeric and ceramic components. This technique converts a computer-aided design (CAD) to a three dimensional (3D) model, and enables layer-per-layer fabrication curing a liquid resin with UV-light or laser source. However, the use of stereolithography in tissue engineering has not been significantly explored possibly due to the lack of commercially available implantable or biocompatible materials from the SL industry. This thesis seeks to develop a range of new bio-compatible/degradable materials that are compatible with a commercial 3D direct manufacture system (envisionTEC Desktop). Firstly, development and modification of microstereolithography equipments were undertaken in order to allow some understanding on the techniques and the process involved in microstereolithography technique. Secondly, a selection of multifunctional polymer and calcium phosphate were studied in order to formulate biodegradable photopolymer resin for specific tissue engineering applications. A 3D structure was successfully fabricated from the formulated photocurable resins. They were then sintered at high temperature for polymer removal, to obtain a ceramic of the desired porosity. Mechanical properties, morphology and calcium phosphate content of the sintered polymers were characterised and investigated with SEM and XRD, respectively. The addition of calcium phosphate coupled with high temperature sintering, had a significant effect on the mechanical properties exhibited by the bioceramic. The successful fabrication of novel bioceramic polymer composite with MSL technique offers the possibility of designing complex tissue scaffolds with optimum mechanical properties for specific tissue engineering applications.

Item Type:	Thesis or Dissertation (PhD)
Subjects:	R Medicine > R Medicine (General) T Technology > TA Engineering (General). Civil engineering (General)
Library of Congress Subject Headings (LCSH):	Three-dimensional printing, Tissue engineering, Biomedical materials
Date:	2012
Institution:	University of Warwick
Theses Department:	School of Engineering
Thesis Type:	PhD
Publication Status:	Unpublished
Supervisor(s)/Advisor:	Covington, James A., 1973-
Sponsors:	Malaysia. Jabatan Perkhidmatan Awam
Extent:	xv, 202 leaves : ill., charts
Language:	eng
URI:	http://wrap.warwick.ac.uk/id/eprint/49636

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