Talib, Marina (2012) Fabrication and characterisation of 3 dimensional scaffold for tissue engineering application via microstereolithography technique. PhD thesis, University of Warwick.

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Abstract

Microstereolithography is a method used for rapid prototyping of polymeric and ceramic
components. This technique converts a computer-aided design (CAD) to a three
dimensional (3D) model, and enables layer-per-layer fabrication curing a liquid resin
with UV-light or laser source. However, the use of stereolithography in tissue
engineering has not been significantly explored possibly due to the lack of commercially
available implantable or biocompatible materials from the SL industry. This thesis seeks
to develop a range of new bio-compatible/degradable materials that are compatible with a
commercial 3D direct manufacture system (envisionTEC Desktop). Firstly, development
and modification of microstereolithography equipments were undertaken in order to
allow some understanding on the techniques and the process involved in
microstereolithography technique. Secondly, a selection of multifunctional polymer and
calcium phosphate were studied in order to formulate biodegradable photopolymer resin
for specific tissue engineering applications. A 3D structure was successfully fabricated
from the formulated photocurable resins. They were then sintered at high temperature for
polymer removal, to obtain a ceramic of the desired porosity. Mechanical properties,
morphology and calcium phosphate content of the sintered polymers were characterised
and investigated with SEM and XRD, respectively. The addition of calcium phosphate
coupled with high temperature sintering, had a significant effect on the mechanical
properties exhibited by the bioceramic. The successful fabrication of novel bioceramic
polymer composite with MSL technique offers the possibility of designing complex
tissue scaffolds with optimum mechanical properties for specific tissue engineering
applications.

Item Type:	Thesis or Dissertation (PhD)
Subjects:	R Medicine > R Medicine (General) T Technology > TA Engineering (General). Civil engineering (General)
Library of Congress Subject Headings (LCSH):	Three-dimensional printing, Tissue engineering, Biomedical materials
Official Date:	2012
Dates:	Date Event 2012 Submitted
Institution:	University of Warwick
Theses Department:	School of Engineering
Thesis Type:	PhD
Publication Status:	Unpublished
Supervisor(s)/Advisor:	Covington, James A., 1973-
Sponsors:	Malaysia. Jabatan Perkhidmatan Awam
Extent:	xv, 202 leaves : ill., charts
Language:	eng
URI:	http://wrap.warwick.ac.uk/id/eprint/49636

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