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Preparation and characterization of iron oxide-silica composite particles using mesoporous SBA-15 silica as template and their internalization into mesenchymal stem cell and human bone cell lines
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Yiu, Humphrey H. P., Maple, Martin J., Lees, Martin R., Palona, Iryna, El Haj, Alicia J. and Dobson, Jon (2010) Preparation and characterization of iron oxide-silica composite particles using mesoporous SBA-15 silica as template and their internalization into mesenchymal stem cell and human bone cell lines. IEEE Transactions on NanoBioscience, Vol.9 (No.3). pp. 165-170. doi:10.1109/TNB.2010.2053770 ISSN 1536-1241.
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Official URL: http://dx.doi.org/10.1109/TNB.2010.2053770
Abstract
A new procedure for preparing iron oxide-silica nanocomposite particles using SBA-15 mesoporous silica as a template is described. These composite materials retained the 2-D hexagonal structure of the SBA-15 template. Transmission electron micrograms of the particles depicted the formation of iron oxide nanocrystals inside the mesochannels of SBA-15 silica framework. Powder x-ray diffraction showed that the iron oxide core of the composite particles consists of a mixture of maghemite (gamma-Fe2O3) and heamatite (alpha-Fe2O3), which is the predominant component. Superconducting quantum interference device (SQUID) magnetometry studies showed that these iron oxide-silica composite materials exhibit superparamagnetic properties. On increasing the iron oxide content, the composite particles exhibited a stronger response to magnetic fields but a less homogeneous core, with some large iron oxide particles which were thought to be formed outside the mesochannels of the SBA-15 template. Internalization of these particles into human cell lines (mesenchymal stem cells and human bone cells), which indicates their potential in medicine and biotechnology, is also discussed.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry T Technology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||
| Journal or Publication Title: | IEEE Transactions on NanoBioscience | ||||
| Publisher: | IEEE | ||||
| ISSN: | 1536-1241 | ||||
| Official Date: | September 2010 | ||||
| Dates: |
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| Volume: | Vol.9 | ||||
| Number: | No.3 | ||||
| Number of Pages: | 6 | ||||
| Page Range: | pp. 165-170 | ||||
| DOI: | 10.1109/TNB.2010.2053770 | ||||
| Status: | Not Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Royal Society (Great Britain), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) |
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