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Oseltamivir for treatment and prevention of pandemic influenza A/H1N1 virus infection in households, Milwaukee, 2009
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Goldstein, Edward, Cowling, Benjamin J., O'Hagan, Justin J., Danon, Leon, Fang, Vicky J., Hagy, Angela, Miller, Joel C., Reshef, David, Robins, James, Biedrzycki, Paul and Lipsitch, Marc (2010) Oseltamivir for treatment and prevention of pandemic influenza A/H1N1 virus infection in households, Milwaukee, 2009. BMC Infectious Diseases, Vol.10 . Article no. 211. doi:10.1186/1471-2334-10-211 ISSN 1471-2334.
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Official URL: http://dx.doi.org/10.1186/1471-2334-10-211
Abstract
Background: During an influenza pandemic, a substantial proportion of transmission is thought to occur in households. We used data on influenza progression in individuals and their contacts collected by the City of Milwaukee Health Department (MHD) to study the transmission of pandemic influenza A/H1N1 virus in 362 households in Milwaukee, WI, and the effects of oseltamivir treatment and chemoprophylaxis.
Methods: 135 households had chronological information on symptoms and oseltamivir usage for all household members. The effect of oseltamivir treatment and other factors on the household secondary attack rate was estimated using univariate and multivariate logistic regression with households as the unit of analysis. The effect of oseltamivir treatment and other factors on the individual secondary attack rate was estimated using univariate and multivariate logistic regression with individual household contacts as the unit of analysis, and a generalized estimating equations approach was used to fit the model to allow for clustering within households.
Results: Oseltamivir index treatment on onset day or the following day (early treatment) was associated with a 42% reduction (OR: 0.58, 95% CI: 0.19, 1.73) in the odds of one or more secondary infections in a household and a 50% reduction (OR: 0.5, 95% CI: 0.17, 1.46) in the odds of a secondary infection in individual contacts. The confidence bounds are wide due to a small sample of households with early oseltamivir index usage - in 29 such households, 5 had a secondary attack. Younger household contacts were at higher risk of infection (OR: 2.79, 95% CI: 1.50-5.20).
Conclusions: Early oseltamivir treatment may be beneficial in preventing H1N1pdm influenza transmission; this may have relevance to future control measures for influenza pandemics. Larger randomized trials are needed to confirm this finding statistically.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QR Microbiology > QR355 Virology | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science, Engineering and Medicine > Science > Mathematics |
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| Journal or Publication Title: | BMC Infectious Diseases | ||||
| Publisher: | BioMed Central Ltd. | ||||
| ISSN: | 1471-2334 | ||||
| Official Date: | 20 July 2010 | ||||
| Dates: |
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| Volume: | Vol.10 | ||||
| Number of Pages: | 7 | ||||
| Page Range: | Article no. 211 | ||||
| DOI: | 10.1186/1471-2334-10-211 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||
| Funder: | US National Institutes of Health, Science & Technology Directorate, Department of Homeland Security, Fogarty International Center, National Institutes of Health | ||||
| Grant number: | 5U01GM076497, 1U54GM088558 |
Data sourced from Thomson Reuters' Web of Knowledge
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