. (2012) Arabidopsis defense against Botrytis cinerea : chronology and regulation deciphered by high-resolution temporal transcriptomic analysis. The Plant Cell, Vol.24 (No.9). pp. 3530-3557. ISSN 1040-4651

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Abstract

Transcriptional reprogramming forms a major part of a plant’s response to pathogen infection. Many individual components and pathways operating during plant defense have been identified, but our knowledge of how these different components interact is still rudimentary. We generated a high-resolution time series of gene expression profiles from a single Arabidopsis thaliana leaf during infection by the necrotrophic fungal pathogen Botrytis cinerea. Approximately one-third of the Arabidopsis genome is differentially expressed during the first 48 h after infection, with the majority of changes in gene expression occurring before significant lesion development. We used computational tools to obtain a detailed chronology of the defense response against B. cinerea, highlighting the times at which signaling and metabolic processes change, and identify transcription factor families operating at different times after infection. Motif enrichment and network inference predicted regulatory interactions, and testing of one such prediction identified a role for TGA3 in defense against necrotrophic pathogens. These data provide an unprecedented level of detail about transcriptional changes during a defense response and are suited to systems biology analyses to generate predictive models of the gene regulatory networks mediating the Arabidopsis response to B. cinerea.

Item Type:	Journal Article
Subjects:	Q Science > QK Botany
Divisions:	Faculty of Science > Life Sciences (2010- ) Faculty of Science > Molecular Organisation and Assembly in Cells (MOAC) Faculty of Science > Statistics Faculty of Science > Centre for Systems Biology
Library of Congress Subject Headings (LCSH):	Arabidopsis thaliana -- Physiology, Arabidopsis thaliana -- Disease and pest resistance, Arabidopsis thaliana -- Defenses, Botrytis cinerea, Plant genetic regulation
Journal or Publication Title:	The Plant Cell
Publisher:	American Society of Plant Biologists
ISSN:	1040-4651
Date:	September 2012
Volume:	Vol.24
Number:	No.9
Page Range:	pp. 3530-3557
Identification Number:	10.1105/tpc.112.102046
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access
Funder:	Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC), L'Oréal (Firm), Unesco, National Science Foundation (U.S.) (NSF)
Grant number:	BB/F005806/1 (BBSRC), 1021861 (NSF)
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URI:	http://wrap.warwick.ac.uk/id/eprint/50147

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