Black, C. (Corrinda), Bagust, A., Boland, A., Walker, S., McLeod, C., De Verteuil, R. (Robyn), Ayres, J. G., Bain, L. (Lynda), Thomas, Sian, Godden, D. J. (David John) and Waugh, Norman. (2006) The clinical effectiveness and cost-effectiveness of computed tomography screening for lung cancer : systematic reviews. Health Technology Assessment, Vol.10 (No.3). ISSN 1366-5278

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Abstract

Screening for lung cancer has been the subject of debate for the past three decades. This has largely stemmed from the results of chest X-ray screening studies where improvements in survival were obtained but without reductions in disease-specific, or total, mortality. The debate raises two issues: the design of studies to evaluate screening for lung cancer, in particular the choice of comparator; and the potential role of overdiagnosis of well-differentiated, slow-growing tumours that would not have led to symptoms or death in the lifetime of the affected patient. Lung cancer is the leading cause of death from cancer in the UK, killing approximately 34,000 people per year. By the time symptoms develop, the tumour is often at an advanced stage and the prognosis is bleak. Treatment at a less advanced stage of disease with surgical resection has been shown to substantially reduce mortality. Screening would be attractive if it could detect presymptomatic lung cancer at a stage when surgical intervention is feasible.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences
Library of Congress Subject Headings (LCSH):	Lungs -- Cancer -- Diagnosis, Tomography -- Cost effectiveness
Journal or Publication Title:	Health Technology Assessment
Publisher:	National Coordinating Centre for Health Technology Assessment
ISSN:	1366-5278
Date:	2006
Volume:	Vol.10
Number:	No.3
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access
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URI:	http://wrap.warwick.ac.uk/id/eprint/50152

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