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Is vitamin K consumption associated with cardio-metabolic disorders? A systematic review

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Rees, Karen, Guraewal, Sanjeet, Wong, Yim Lun, Majanbu, Dauda L., Mavrodaris, Angelique, Stranges, Saverio, Kandala, Ngianga-Bakwin, Clarke, Aileen and Franco, Oscar H. (2010) Is vitamin K consumption associated with cardio-metabolic disorders? A systematic review. Maturitas, Vol.67 (No.2). pp. 121-128. doi:10.1016/j.maturitas.2010.05.006 ISSN 0378-5122.

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Official URL: http://dx.doi.org/10.1016/j.maturitas.2010.05.006

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Abstract

Associations have been found between various micronutrients and cardio-metabolic outcomes. Vitamin K deficiency has been associated with increased calcification of the main arteries and with insulin resistance. The present study aimed to examine the association between vitamin K intake and cardiometabolic outcomes including cardiovascular disease, type 2 diabetes and the metabolic syndrome.

A systematic review of the literature was performed in January 2010. Nine electronic databases, and trial registers, reference lists of retrieved articles and citations were searched. Intervention, cohort, case-control or cross-sectional studies in adults were included if they examined the association between vitamin K levels (dietary intake, biomarkers, supplements) on clinical outcomes relevant to cardiometabolic disease.

Five studies met the inclusion criteria (1 trial, 4 cohort studies). Heterogeneity of designs, exposures/interventions and outcomes meant that meta-analysis was not possible. No associations were found between vitamin K1 intake and coronary heart disease (CHD) (4 cohorts) or stroke (2 cohorts) in multivariate analyses. No differences were seen in the prevalence of diabetes in a trial of vitamin K1 supplementation. Two cohorts examined the effects of vitamin K2 intake on the incidence of CHD; both found significant associations where higher vitamin K2 intake was associated with fewer CHD events.

Few studies have examined the effects of vitamin K intake on clinical outcomes relevant to cardiometabolic disorders. None of the studies used biomarkers. Currently there is no evidence for an effect of vitamin K1, but results for vitamin K2 look promising. Further prospective studies are required to confirm these findings. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) > Warwick Evidence
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Vitamin K, Vitamin K2, Cardiovascular system -- Diseases -- Pathogenesis -- Research, Non-insulin-dependent diabetes -- Pathogenesis -- Research, Metabolic syndrome, Systematic reviews (Medical research)
Journal or Publication Title: Maturitas
Publisher: Elsevier Ireland Ltd.
ISSN: 0378-5122
Official Date: October 2010
Dates:
DateEvent
October 2010Published
Volume: Vol.67
Number: No.2
Number of Pages: 8
Page Range: pp. 121-128
DOI: 10.1016/j.maturitas.2010.05.006
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

Data sourced from Thomson Reuters' Web of Knowledge

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