Noffke, Anna Louise, Habtemariam, Abraha, Pizarro, Ana M. and Sadler, P. J.. (2012) Designing organometallic compounds for catalysis and therapy. Chemical Communications, Vol.48 (No.43). pp. 5219-5246. ISSN 1359-7345

Text WRAP_Habtemariam486_ChemComm2012_48_5219_Anna Louisa Noffke_deposit.pdf - Accepted Version Restricted to Repository staff only until 20 March 2013. Download (3095Kb)

Abstract

Bioorganometallic chemistry is a rapidly developing area of research. In recent years organometallic compounds have provided a rich platform for the design of effective catalysts, e.g. for olefin metathesis and transfer hydrogenation. Electronic and steric effects are used to control both the thermodynamics and kinetics of ligand substitution and redox reactions of metal ions, especially Ru II. Can similar features be incorporated into the design of targeted organometallic drugs? Such complexes offer potential for novel mechanisms of drug action through incorporation of outer-sphere recognition of targets and controlled activation features based on ligand substitution as well as metal- and ligand-based redox processes. We focus here on η 6-arene, η 5-cyclopentadienyl sandwich and half-sandwich complexes of Fe II, Ru II, Os II and Ir III with promising activity towards cancer, malaria, and other conditions. © 2012 The Royal Society of Chemistry.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Organometallic compounds, Antimalarials, Antineoplastic agents, Catalysis, Tumors, Thermodynamics
Journal or Publication Title:	Chemical Communications
Publisher:	Royal Society of Chemistry
ISSN:	1359-7345
Date:	28 May 2012
Volume:	Vol.48
Number:	No.43
Page Range:	pp. 5219-5246
Identification Number:	10.1039/c2cc30678f
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	European Research Council (ERC), Economic and Social Research Council (Great Britain) (ESRC), Advantage West Midlands (AWM), European Regional Development Fund (ERDF)
Grant number:	247450 (ERC)
References:	1. C. G. Hartinger and P. J. Dyson, Chem. Soc. Rev., 2009, 38, 391-401. 2. R. Jira, Angew. Chem. Int. Ed., 2009, 48, 9034-9037. 3. J. R. Zoeller, V. H. Agreda, S. L. Cook, N. L. Lafferty, S. W. Polichnowski and D. M. Pond, Catal. Today, 1992, 13, 73-91. 4. A. Yabluchanskiy, P. Sawle, S. Homer-Vanniasinkam, C. J. Green, R. Foresti and R. Motterlini, Crit. Care Med., 2012, 40, 544-552. 5. U. Schatzschneider, Inorg. Chim. Acta, 2011, 374, 19-23. 6. R. Alberto and R. Motterlini, Dalton Trans., 2007, 36, 1651-1660. 7. M. Desmard, R. Foresti, D. Morin, M. Dagoussat, A. Berdeaux, E. Denamur, S. H. Crook, B. E. Mann, D. Scapens, P. Montravers, J. Boczkowski and R. Motterlini, Antioxid. Redox Signal., 2012, 16, 153-163. 8. R. Motterlini and L. E. Otterbein, Nat. Rev. Drug Discov., 2010, 9, 728-743. 9. K. M. Hindi, M. J. Panzner, C. A. Tessier, C. L. Cannon and W. J. Youngs, Chem. Rev., 2009, 109, 3859-3884. 10. A. Alama, M. Viale, M. Cilli, C. Bruzzo, F. Novelli, B. Tasso and F. Sparatore, Invest. New Drugs, 2009, 27, 124-130. 11. A. Alama, B. Tasso, F. Novelli and F. Sparatore, Drug Discov. Today, 2009, 14, 500-508. 12. L. Rocamora-Reverte, E. Carrasco-García, J. Ceballos-Torres, S. Prashar, G. N. Kaluđerović, J. A. Ferragut and S. Gómez-Ruiz, ChemMedChem, 2012, 7, 301-310. 13. S. M. Page, S. R. Boss and P. D. Barker, Future Med. Chem., 2009, 1, 541-559. 14. P. T. T. Wong and D. G. Brewer, Can. J. Chem., 1968, 46, 131-138. 15. R. Patiño, M. Campos and L. A. Torres, Inorg. Chem., 2007, 46, 9332-9336. 16. U. Jungwirth, C. R. Kowol, B. K. Keppler, C. G. Hartinger, W. Berger and P. Heffeter, Antioxid. Redox Signal., 2011, 15, 1085-1127. 17. Y. Kuninobu and K. Takai, Chem. Rev., 2011, 111, 1938-1953. 18. G. C. Vougioukalakis and R. H. Grubbs, Chem. Rev., 2010, 110, 1746-1787. 19. N. Selander and . l. n. J. Szabó, Chem. Rev., 2010, 111, 2048-2076. 20. J. F. Hull, D. Balcells, J. D. Blakemore, C. D. Incarvito, O. Eisenstein, G. W. Brudvig and R. H. Crabtree, J. Am. Chem. Soc., 2009, 131, 8730-8731. 21. T. P. Brewster, J. D. Blakemore, N. D. Schley, C. D. Incarvito, N. Hazari, G. W. Brudvig and R. H. Crabtree, Organometallics, 2011, 30, 965-973. 22. T. M. Trnka and R. H. Grubbs, Acc. Chem. Res., 2001, 34, 18-29. 23. R. H. Grubbs, Tetrahedron, 2004, 60, 7117-7140. 24. G. C. Vougioukalakis and R. H. Grubbs, Chem. Rev., 2010, 110, 1746-1787. 25. M. S. Sanford, J. A. Love and R. H. Grubbs, J. Am. Chem. Soc., 2001, 123, 6543-6554. 26. B. Therrien, Coord. Chem. Rev., 2009, 253, 493-519. 27. L. Jafarpour, J. Huang, E. D. Stevens and S. P. Nolan, Organometallics, 1999, 18, 3760-3763. 28. L. Oehninger, H. Alborzinia, S. Ludewig, K. Baumann, S. Wölfl and I. Ott, ChemMedChem, 2011, 6, 2142-2145. 29. X. Wu, C. Wang and J. Xiao, Platinum Metals Rev., 2010, 54, 3-19. 30. S. Hashiguchi, A. Fujii, J. Takehara, T. Ikariya and R. Noyori, J. Am. Chem. Soc., 1995, 117, 7562-7563. 31. A. Fujii, S. Hashiguchi, N. Uematsu, T. Ikariya and R. Noyori, J. Am. Chem. Soc., 1996, 118, 2521-2522. 32. R. Noyori and T. Ohkuma, Angew. Chem. Int. Ed., 2001, 40, 40-73. 33. R. Noyori and S. Hashiguchi, Acc. Chem. Res., 1997, 30, 97-102. 34. E. Steckhan, S. Herrmann, R. Ruppert, J. Thömmes and C. Wandrey, Angew. Chem. Int. Ed., 1990, 29, 388-390. 35. R. Ruppert, S. Herrmann and E. Steckhan, Chem. Commun., 1988, 1150-1151. 36. H. Gröger, W. Hummel, S. Buchholz, K. Drauz, T. V. Nguyen, C. Rollmann, H. Hüsken and K. Abokitse, Org. Lett., 2003, 5, 173-176. 37. W. A. van der Donk and H. Zhao, Curr. Opin. Biotechnol., 2003, 14, 421-426. 38. H. Zhao and W. A. van der Donk, Curr. Opin. Biotechnol., 2003, 14, 583-589. 39. A. B. Chaplin and P. J. Dyson, Organometallics, 2007, 26, 4357-4360. 40. M. C. Carrión, F. Sep lveda, F. l. A. Jalón, . R. Manzano and A. M. Rodr guez, Organometallics, 2009, 28, 3822-3833. 41. C. A. Sandoval, F. Bie, A. Matsuoka, Y. Yamaguchi, H. Naka, Y. Li, K. Kato, N. Utsumi, K. Tsutsumi, T. Ohkuma, K. Murata and R. Noyori, Chem. Asian J., 2010, 5, 806-816. 42. C. Leiva, H. Christine Lo and R. H. Fish, J. Organomet. Chem., 2010, 695, 145-150. 43. X. Wu, J. Liu, D. Di Tommaso, J. A. Iggo, C. R. A. Catlow, J. Bacsa and J. Xiao, Chem. Eur. J., 2008, 14, 7699-7715. 44. J. Lutz, F. Hollmann, T. V. Ho, A. Schnyder, R. H. Fish and A. Schmid, J. Organomet. Chem., 2004, 689, 4783-4790. 45. H. C. Lo, C. Leiva, O. Buriez, J. B. Kerr, M. M. Olmstead and R. H. Fish, Inorg. Chem., 2001, 40, 6705-6716. 46. S. Ogo, O. Buriez, J. B. Kerr and R. H. Fish, J. Organomet. Chem., 1999, 589, 66-74. 47. H. C. Lo, O. Buriez, J. B. Kerr and R. H. Fish, Angew. Chem. Int. Ed., 1999, 38, 1429-1432. 48. F. Hollmann, A. Kleeb, K. Otto and A. Schmid, Tetrahedron: Asymm, 2005, 16, 3512-3519. 49. S. Takebayashi, N. Dabral, M. Miskolzie and S. H. Bergens, J. Am. Chem. Soc., 2011, 133, 9666-9669. 50. M. M. Grau, M. Poizat, I. W. C. E. Arends and F. Hollmann, Appl. Organomet. Chem., 2010, 24, 380-385. 51. A. Schmid, J. S. Dordick, B. Hauer, A. Kiener, W. Wubbolts and B. Withold, Nature, 2001, 409, 258-268 52. S. H. Lee, J. Ryu, D. H. Nam and C. B. Park, Chem. Commun., 2011, 47, 4643-4645. 53. J. Li, J. Yang, F. Wen and C. Li, Chem. Commun., 2011, 47, 7080-7082. 54. R. L. Hayward, Q. C. Schornagel, R. Tente, J. S. Macpherson, R. E. Aird, S. Guichard, A. Habtemariam, P. Sadler and D. I. Jodrell, Cancer Chemother. Pharmacol., 2005, 55, 577-583. 55. T. R. Ward, Acc. Chem. Res., 2011, 44, 47-57. 56. M. Yamakawa, I. Yamada and R. Noyori, Angew. Chem. Int. Ed., 2001, 40, 2818-2821. 57. S. Ogo, H. Nakai and Y. Watanabe, J. Am. Chem. Soc., 2002, 124, 597-601. 58. J. Canivet, G. Süss-Fink and P. Štěpnička, Eur. J. Inorg. Chem., 2007, 4736-4742. 59. Y. K. Yan, M. Melchart, A. Habtemariam, A. F. A. Peacock and P. J. Sadler, J. Biol. Inorg. Chem., 2006, 11, 483-488. 60. S. Betanzos-Lara, Z. Liu, A. Habtemariam, A. M. Pizarro, B. Qamar and P. J. Sadler, Angew. Chem. Int. Ed., 2012, doi 10.1002/anie.201108175. 61. Y. Maenaka, T. Suenobu and S. Fukuzumi, J. Am. Chem. Soc., 2011, 134, 367-374. 62. S. Betanzos-Lara, Z. Liu, A. Habtemariam and P. J. Sadler, submitted, 2011. 63. A. Habtemariam, Z. Liu, J. J. Soldevila, A. M. Pizarro and P. J. Sadler, 2011, WO/2011/148124, 88p. 64. C. del Pozo, M. glesias and F. l. S nchez, Organometallics, 2011, 30, 2180-2188. 65. Y. Yano, T. Kojima and S. Fukuzumi, Inorg. Chim. Acta, 2011, 374, 104-111. 66. H. Kopf and P. Kopf-Maier, Angew. Chem. Int. Ed., 1979, 18, 477-478. 67. P. Kopf-Maier, M. Leitner, R. Voigtlander and H. Kopf, Z. Naturforsch., C: Biosci., 1979, 34, 1174-1176. 68. P. Kopf-Maier and H. Kopf, Naturwissenschaften, 1980, 67, 415-416. 69. P. Kopf-Maier, B. Hesse, R. Voigtlander and H. Kopf, J. Cancer Res. Clin. Oncol., 1980, 97, 31-39. 70. P. Kopf-Maier, B. Hesse and H. Kopf, J. Cancer Res. Clin. Oncol., 1980, 96, 43-51. 71. K. Mross, P. Robben-Bathe, L. Edler, J. Baumgart, W. E. Berdel, H. Fiebig and C. Unger, Onkologie, 2000, 23, 576-579. 72. E. Melendez, Critical reviews in oncology/hematology, 2002, 42, 309-315. 73. F. Caruso and M. Rossi, Met Ions Biol Syst, 2004, 42, 353-384. 74. G. Lummen, H. Sperling, H. Luboldt, T. Otto and H. Rubben, Cancer Chemother Pharmacol, 1998, 42, 415-417. 75. N. Kröger, U. R. Kleeberg, K. Mross, L. Edler and D. K. Hossfeld, Onkologie, 2000, 23, 60-62. 76. J. H. Toney and T. J. Marks, J. Am. Chem. Soc., 1985, 107, 947-953. 77. M. L. Guo, Z. J. Guo and P. J. Sadler, J. Biol. Inorg. Chem., 2001, 6, 698-707. 78. A. Erxleben, J. Claffey and M. Tacke, J. Inorg. Biochem., 2010, 104, 390-396. 79. M. Guo, H. Sun, H. J. McArdle, L. Gambling and P. J. Sadler, Biochemistry, 2000, 39, 10023-10033. 80. O. R. Allen, R. J. Knox and P. C. McGowan, Dalton Trans., 2008, 37, 5293-5295. 81. O. R. Allen, A. L. Gott, J. A. Hartley, J. M. Hartley, R. J. Knox and P. C. McGowan, Dalton Trans, 2007, 5082-5090. 82. N. J. Sweeney, O. Mendoza, H. Müller-Bunz, C. Pampillón, F.-J. K. Rehmann, K. Strohfeldt and M. Tacke, J. Organomet. Chem., 2005, 690, 4537-4544. 83. K. Strohfeldt and M. Tacke, Chem. Soc. Rev., 2008, 37, 1174-1187. 84. M. Hogan and M. Tacke, in Medicinal Organometallic Chemistry, eds. G. Jaouen and N. Metzler-Nolte, Springer, Heidelberg Dordrecht London New York, 2010, vol. 32, pp. 119-140. 85. A. Vessières, M.-A. Plamont, C. Cabestaing, J. Claffey, S. Dieckmann, M. Hogan, H. Müller-Bunz, K. Strohfeldt and M. Tacke, J. Organomet. Chem., 2009, 694, 874-879. 86. S. W. Sarsam, D. R. Nutt, K. Strohfeldt and K. A. Watson, in Metallomics, The Royal Society of Chemistry, 2011. 87. M. Hogan, B. Gleeson and M. Tacke, Organometallics, 2010, 29, 1032-1040. 88. F. d. r. Pelletier, V. Comte, A. Massard, M. Wenzel, S. p. Toulot, P. Richard, M. Picquet, P. Le Gendre, O. Zava, F. Edafe, A. Casini and P. J. Dyson, J. Med. Chem., 2010, 53, 6923-6933. 89. C. Elschenbroich, Organometallics, 3 edn., Wiley VCH, Weinheim, 2006. 90. sigma-aldrich, benzene - material safety data sheet, 2011. 91. P. L. Olliaro and W. R. Taylor, J. Exp. Biol., 2003, 206, 3753-3759. 92. C. Biot and D. Dive, in Medicinal Organometallic Chemistry, eds. N. Metzler-Nolte and G. Jaouen, Springer, Heidelberg Dordrecht London New York, 2010, vol. 32, pp. 155-193. 93. Sanofi-Aventis, http://clinicaltrials.gov/ct2/show/NCT00988507, 2011. 94. R. Arancibia, F. Dubar, B. Pradines, I. Forfar, D. Dive, A. H. Klahn and C. Biot, Bioorg. Med. Chem., 2010, 18, 8085-8091. 95. U. S. F. D. Administration, http://web.archive.org/web/20070619012859/http://www.fda.gov/cder/news/tamoxifen/, 1998. 96. S. Top, J. Tang, A. Vessieres, D. Carrez, C. Provot and G. Jaouen, Chem. Commun., 1996, 955-956. 97. S. Top, B. Dauer, J. Vaissermann and G. Jaouen, J. Organomet. Chem., 1997, 541, 355-361. 98. S. Top, I. Efremenko, M. N. Rager, A. Vessieres, P. Yaswen, G. Jaouen and R. H. Fish, Inorg. Chem., 2011, 50, 271-284. 99. M. Gormen, P. Pigeon, S. Top, E. A. Hillard, M. Huché, C. G. Hartinger, F. de Montigny, M.-A. Plamont, A. Vessières and G. Jaouen, ChemMedChem, 2010, 5, 2039-2050. 100. E. A. Hillard, A. Vessieres and G. Jaouen, in Medicinal Organometallic Chemistry, eds. G. Jaouen and N. Metzler-Nolte, Springer, Heidelberg Dordrecht London New York, 2010, vol. 32, pp. 81-117. 101. Y. L. Tan, P. Pigeon, E. A. Hillard, S. Top, M. A. Plamont, A. Vessieres, M. J. McGlinchey, H. Muller-Bunz and G. Jaouen, Dalton Trans., 2009, 38, 10871-10881. 102. D. Hamels, P. M. Dansette, E. A. Hillard, S. Top, A. Vessieres, P. Herson, G. Jaouen and D. Mansuy, Angew. Chem. Int. Ed., 2009, 48, 9124-9126. 103. O. Zekri, E. A. Hillard, S. Top, A. Vessieres, P. Pigeon, M. A. Plamont, M. Huche, S. Boutamine, M. J. McGlinchey, H. Muller-Bunz and G. Jaouen, Dalton Trans., 2009, 38, 4318-4326. 104. D. Plazuk, A. Vessieres, E. A. Hillard, O. Buriez, E. Labbe, P. Pigeon, M. A. Plamont, C. Amatore, J. Zakrzewski and G. Jaouen, J. Med. Chem., 2009, 52, 4964-4967. 105. E. Meggers, G. E. Atilla-Gokcumen, K. Grundler, C. Frias and A. Prokop, Dalton Trans., 2009, 38, 10882-10888. 106. R. Anand, J. Maksimoska, N. Pagano, E. Y. Wong, P. A. Gimotty, S. L. Diamond, E. Meggers and R. Marmorstein, J. Med. Chem., 2009, 52, 1602-1611. 107. E. Meggers, Chem. Commun., 2009, 45, 1001-1010. 108. L. Feng, Y. Geisselbrecht, S. Blanck, A. Wilbuer, G. E. Atilla-Gokcumen, P. Filippakopoulos, K. Kraling, M. A. Celik, K. Harms, J. Maksimoska, R. Marmorstein, G. Frenking, S. Knapp, L. O. Essen and E. Meggers, J. Am. Chem. Soc., 2011, 133, 5976-5986. 109. E. Meggers, Angew. Chem. Int. Ed., 2011, 50, 2442-2448. 110. E. D. Harris, Annu. Rev. Nutr., 2000, 20, 291-310. 111. G. Suss-Fink, Dalton Trans., 2010, 39, 1673-1688. 112. C. S. Allardyce, P. J. Dyson, D. J. Ellis and S. L. Heath, Chem. Commun., 2001, 37, 1396-1397. 113. C. Scolaro, A. Bergamo, L. Brescacin, R. Delfino, M. Cocchietto, G. Laurenczy, T. J. Geldbach, G. Sava and P. J. Dyson, J. Med. Chem., 2005, 48, 4161-4171. 114. W. H. Ang, E. Daldini, C. Scolaro, R. Scopelliti, L. Juillerat-Jeannerat and P. J. Dyson, Inorg. Chem., 2006, 45, 9006-9013. 115. P. J. Dyson and G. Sava, Dalton Trans., 2006, 35, 1929-1933. 116. A. Bergamo, A. Masi, P. J. Dyson and G. Sava, Int. J. Oncol., 2008, 33, 1281-1289. 117. A. Bergamo, A. Masi, A. F. Peacock, A. Habtemariam, P. J. Sadler and G. Sava, J. Inorg. Biochem., 2010, 104, 79-86. 118. R. E. Aird, J. Cummings, A. A. Ritchie, M. Muir, R. E. Morris, H. Chen, P. J. Sadler and D. I. Jodrell, Br. J. Cancer, 2002, 86, 6. 119. S. M. Guichard, R. Else, E. Reid, B. Zeitlin, R. Aird, M. Muir, M. Dodds, H. Fiebig, P. J. Sadler and D. I. Jodrell, Biochem. Pharmacol., 2006, 71, 408-415. 120. A. Casini, A. Karotki, C. Gabbiani, F. Rugi, M. Vasak, L. Messori and P. J. Dyson, Metallomics, 2009, 1, 434-441. 121. A. Casini, C. Gabbiani, F. Sorrentino, M. P. Rigobello, A. Bindoli, T. J. Geldbach, A. Marrone, N. Re, C. G. Hartinger, P. J. Dyson and L. Messori, J. Med. Chem., 2008, 51, 6773-6781. 122. W. H. Ang, A. Casini, G. Sava and P. J. Dyson, J. Organomet. Chem., 2011, 696, 989-998. 123. F. Mendes, M. Groessl, A. A. Nazarov, Y. O. Tsybin, G. Sava, I. Santos, P. J. Dyson and A. Casini, J. Med. Chem., 2011, 54, 2196-2206. 124. A. Dorcier, W. H. Ang, S. Bolaño, L. Gonsalvi, L. Juillerat-Jeannerat, G. Laurenczy, M. Peruzzini, A. D. Phillips, F. Zanobini and P. J. Dyson, Organometallics, 2006, 25, 4090-4096. 125. A. Dorcier, C. G. Hartinger, R. Scopelliti, R. H. Fish, B. K. Keppler and P. J. Dyson, J. Inorg. Biochem., 2008, 102, 1066-1076. 126. A. Casini, F. Edafe, M. Erlandsson, L. Gonsalvi, A. Ciancetta, N. Re, A. Ienco, L. Messori, M. Peruzzini and P. J. Dyson, Dalton Trans., 2010, 39, 5556-5563. 127. S. Betanzos-Lara, A. Habtemariam, G. J. Clarkson and P. J. Sadler, Eur. J. Inorg. Chem., 2011, 3257-3264. 128. M. Melchart, A. Habtemariam, O. Novakova, S. A. Moggach, F. P. A. Fabbiani, S. Parsons, V. Brabec and P. J. Sadler, Inorg. Chem., 2007, 46, 8950-8962. 129. M. Melchart, A. Habtemariam, S. Parsons and P. J. Sadler, J. Inorg. Biochem., 2007, 101, 1903-1912. 130. A. M. Pizarro, M. Melchart, A. Habtemariam, L. Salassa, F. P. Fabbiani, S. Parsons and P. J. Sadler, Inorg. Chem., 2010, 49, 3310-3319. 131. A. M. Hayes, D. J. Morris, G. J. Clarkson and M. Wills, J. Am. Chem. Soc., 2005, 127, 7318-7319. 132. M. Ito, N. Tejima, M. Yamamura, Y. Endo and T. Ikariya, Organometallics, 2010, 29, 1886-1889. 133. F. Wang, A. Habtemariam, E. P. L. van der Geer, R. Fernandez, M. Melchart, R. J. Deeth, R. Aird, S. Guichard, F. P. A. Fabbiani, P. Lozano-Casal, I. D. H. Oswald, D. I. Jodrell, S. Parsons and P. J. Sadler, Proc. Nat. Sci. USA, 2005, 102, 18269-18274. 134. R. Fernandez, M. Melchart, A. Habtemariam, S. Parsons and P. J. Sadler, Chem. Eur. J., 2004, 10, 5173-5179. 135. M. Melchart, A. Habtemariam, S. Parsons, S. A. Moggach and P. J. Sadler, Inorg. Chim. Acta, 2006, 359, 3020-3028. 136. F. Wang, H. Chen, S. Parsons, I. D. Oswald, J. E. Davidson and P. J. Sadler, Chem. Eur. J., 2003, 9, 5810-5820. 137. M. Jennerwein and P. A. Andrews, Drug Metab. Dispos., 1995, 23, 178-184. 138. S. Betanzos-Lara, L. Salassa, A. Habtemariam and P. J. Sadler, Chem. Commun., 2009, 45, 6622-6624. 139. A. M. Pizarro, A. Habtemariam and P. J. Sadler, in Medicinal Organometallic Chemistry, eds. G. Jaouen and N. Metzler-Nolte, Springer, Heidelberg Dordrecht London New York, 2010, vol. 32, pp. 21-56. 140. A. Habtemariam, M. Melchart, R. Fernandez, S. Parsons, I. D. H. Oswald, A. Parkin, F. P. A. Fabbiani, J. E. Davidson, A. Dawson, R. E. Aird, D. I. Jodrell and P. J. Sadler, J. Med. Chem., 2006, 49, 6858-6868. 141. A. F. A. Peacock, A. Habtemariam, R. Fernández, V. Walland, F. P. A. Fabbiani, S. Parsons, R. E. Aird, D. I. Jodrell and P. J. Sadler, J. Am. Chem. Soc., 2006, 128, 1739-1748. 142. A. F. A. Peacock, M. Melchart, R. J. Deeth, A. Habtemariam, S. Parsons and P. J. Sadler, Chem. Eur. J., 2007, 13, 2601-2613. 143. A. F. Peacock, A. Habtemariam, S. A. Moggach, A. Prescimone, S. Parsons and P. J. Sadler, Inorg. Chem., 2007, 46, 4049-4059. 144. A. F. A. Peacock, S. Parsons and P. J. Sadler, J. Am. Chem. Soc., 2007, 129, 3348. 145. S. H. van Rijt, A. F. Peacock, R. D. Johnstone, S. Parsons and P. J. Sadler, Inorg. Chem., 2009, 48, 1753-1762. 146. F. Wang, J. Xu, A. Habtemariam, J. Bella and P. J. Sadler, J. Am. Chem. Soc., 2005, 127, 17734-17743. 147. H. Petzold and P. J. Sadler, Chem. Commun., 2008, 44, 4413-4415. 148. H. Petzold, J. Xu and P. J. Sadler, Angew. Chem. Int. Ed., 2008, 47, 3008-3011. 149. T. Sriskandakumar, H. Petzold, P. C. A. Bruijnincx, A. Habtemariam, P. J. Sadler and P. Kennepohl, J. Am. Chem. Soc., 2009, 131, 13355-13361. 150. W. Hu, Q. Luo, X. Ma, K. Wu, J. Liu, Y. Chen, S. Xiong, J. Wang, P. J. Sadler and F. Wang, Chem. Eur. J., 2009, 15, 6586-6594. 151. F. Giannini, G. Suss-Fink and J. Furrer, Inorg. Chem., 2011, 50, 10552-10554. 152. S. J. Dougan, M. Melchart, A. Habtemariam, S. Parsons and P. J. Sadler, Inorg. Chem., 2006, 45, 10882-10894. 153. S. J. Dougan, A. Habtemariam, S. E. McHale, S. Parsons and P. J. Sadler, Proc. Nat. Sci. USA, 2008, 105, 11628-11633. 154. Y. Fu, A. Habtemariam, A. M. Pizarro, S. H. van Rijt, D. J. Healey, P. A. Cooper, S. D. Shnyder, G. J. Clarkson and P. J. Sadler, J. Med. Chem., 2010, 53, 8192-8196. 155. Y. Fu, A. Habtemariam, A. M. Basri, D. Braddick, G. J. Clarkson and P. J. Sadler, Dalton Trans., 2011, 40, 10553-10562. 156. T. Bugarcic, A. Habtemariam, R. J. Deeth, F. P. A. Fabbiani, S. Parsons and P. J. Sadler, Inorg. Chem., 2009, 48, 9444-9453. 157. B. Therrien, G. Suss-Fink, P. Govindaswamy, A. K. Renfrew and P. J. Dyson, Angew. Chem. Int. Ed., 2008, 47, 3773-3776. 158. O. Zava, J. Mattsson, B. Therrien and P. J. Dyson, Chem. Eur. J., 2010, 16, 1428-1431. 159. A. Pitto-Barry, N. P. E. Barry, O. Zava, R. Deschenaux and B. Therrien, Chem. Asian J., 2011, 6, 1595-1603. 160. A. Pitto-Barry, N. P. E. Barry, O. Zava, R. Deschenaux, P. J. Dyson and B. Therrien, Chem. Eur. J., 2011, 17, 1966-1971. 161. N. P. E. Barry, F. Edafe, P. J. Dyson and B. Therrien, Dalton Trans., 2010, 39, 2816-2820. 162. N. P. E. Barry, F. Edafe and B. Therrien, Dalton Trans., 2011, 40, 7172-7180. 163. N. P. E. Barry, O. Zava, J. Furrer, P. J. Dyson and B. Therrien, Dalton Trans., 2010, 39, 5272-5277. 164. N. P. E. Barry, N. H. Abd Karim, R. Vilar and B. Therrien, Dalton Trans., 2009, 38, 10717-10719. 165. L. K. Filak, G. Muhlgassner, F. Bacher, A. Roller, M. Galanski, M. A. Jakupec, B. K. Keppler and V. B. Arion, Organometallics, 2011, 30, 273-283. 166. I. Turel, J. Kljun, F. Perdih, E. Morozova, V. Bakulev, N. Kasyanenko, J. A. Byl and N. Osheroff, Inorg. Chem., 2010, 49, 10750-10752. 167. J. Kljun, A. K. Bytzek, W. Kandioller, C. Bartel, M. A. Jakupec, C. G. Hartinger, B. K. Keppler and I. Turel, Organometallics, 2011, 30, 2506-2512. 168. S. Grguric-Sipka, I. Ivanovic, G. Rakic, N. Todorovic, N. Gligorijevic, S. Radulovic, V. B. Arion, B. K. Keppler and Z. L. Tesic, Eur. J. Med. Chem., 2010, 45, 1051-1058. 169. W. Kandioller, C. G. Hartinger, A. A. Nazarov, C. Bartel, M. Skocic, M. A. Jakupec, V. B. Arion and B. K. Keppler, Chemistry, 2009, 15, 12283-12291. 170. M. Hanif, S. M. Meier, W. Kandioller, A. Bytzek, M. Hejl, C. G. Hartinger, A. A. Nazarov, V. B. Arion, M. A. Jakupec, P. J. Dyson and B. K. Keppler, J. Inorg. Biochem., 2011, 105, 224-231. 171. M. Hanif, H. Henke, S. M. Meier, S. Martic, M. Labib, W. Kandioller, M. A. Jakupec, V. B. Arion, H. B. Kraatz, B. K. Keppler and C. G. Hartinger, Inorg. Chem., 2010, 49, 7953-7963. 172. S. van Rijt, A. Hebden, T. Amaresekera, R. Deeth, G. Clarkson, S. Parsons, P. McGowan and P. Sadler, J. Med. Chem., 2009, 52, 7753-7764. 173. S. H. van Rijt, A. Mukherjee, A. M. Pizarro and P. J. Sadler, J. Med. Chem., 2010, 53, 840-849. 174. C. Gossens, I. Tavernelli and U. Rothlisberger, J. Phys. Chem. A, 2009, 113, 11888-11897. 175. H. Chen, J. A. Parkinson, R. E. Morris and P. J. Sadler, J. Am. Chem. Soc., 2003, 125, 173-186. 176. H.-K. Liu and P. J. Sadler, Acc. Chem. Res., 2011, 44, 349-359. 177. R. K. Herman and N. B. Dworkin, J. Bacteriol., 1971, 106, 543-550. 178. H. K. Liu, S. J. Berners-Price, F. Wang, J. A. Parkinson, J. Xu, J. Bella and P. J. Sadler, Angew. Chem. Int. Ed., 2006, 45, 8153-8156. 179. H. Chen, J. A. Parkinson, O. Novakova, J. Bella, F. Wang, A. Dawson, R. Gould, S. Parsons, V. Brabec and P. J. Sadler, Proc. Nat. Sci. USA, 2003, 100, 14623-14628. 180. O. Novakova, A. A. Nazarov, C. G. Hartinger, B. K. Keppler and V. Brabec, Biochem. Pharmacol., 2009, 77, 364-374. 181. H.-K. Liu, J. A. Parkinson, J. Bella, F. Wang and P. J. Sadler, Chem. Sci., 2010, 1, 258-270. 182. J. P. Williams, T. Bugarcic, A. Habtemariam, K. Giles, I. Campuzano, P. M. Rodger and P. J. Sadler, J. Am. Soc. Mass. Spectrom., 2009, 20, 1119-1122. 183. T. Bugarcic, O. Novakova, A. Halamikova, L. Zerzankova, O. Vrana, J. Kasparkova, A. Habtemariam, S. Parsons, P. J. Sadler and V. Brabec, J. Med. Chem., 2008, 51, 5310-5319. 184. A. Kisova, L. Zerzankova, A. Habtemariam, P. J. Sadler, V. Brabec and J. Kasparkova, Mol. Pharmacol., 2011, 8, 949-957. 185. J. P. Williams, J. A. Lough, I. Campuzano, K. Richardson and P. J. Sadler, Rapid Commun. Mass Spectrom., 2009, 23, 3563-3569. 186. O. Novakova, J. Kasparkova, V. Bursova, C. A. Hofr, M. Vojtiskova, H. Chen, P. J. Sadler and V. Brabec, Chemistry & Biology, 2005, 12, 9. 187. O. Novakova, J. Malina, T. Suchankova, J. Kasparkova, T. Bugarcic, P. J. Sadler and V. Brabec, Chem. Eur. J., 2010, 16, 5744-5754. 188. Z. Liu, A. Habtemariam, A. M. Pizarro, S. A. Fletcher, A. Kisova, O. Vrana, L. Salassa, P. C. Bruijnincx, G. J. Clarkson, V. Brabec and P. J. Sadler, J. Med. Chem., 2011, 54, 3011-3026. 189. S. Schäfer and W. S. Sheldrick, J. Organomet. Chem., 2007, 692, 1300-1309. 190. J. Ruiz, C. Vicente, C. de Haro and D. Bautista, Dalton Trans., 2009, 38, 5071-5073. 191. T. W. Hambley, Coord. Chem. Rev., 1997, 166, 181-223.
URI:	http://wrap.warwick.ac.uk/id/eprint/50269

Request changes to a record

Actions (login required)

View Item