Exploiting thermoresponsive polymers to modulate lipophilicity : interactions with model membranes
Saaka, Yussif, Deller, Robert C., Rodger, Alison and Gibson, Matthew I.. (2012) Exploiting thermoresponsive polymers to modulate lipophilicity : interactions with model membranes. Macromolecular Rapid Communications, Vol.33 (No.9). pp. 779-784. ISSN 1022-1336Full text not available from this repository.
Official URL: http://dx.doi.org/10.1002/marc.201100873
Upon heating above their lower critical solution temperature (LCST) poly[oligo(ethyleneglycol)methacrylate]s (POEGMA) were shown to undergo a shift in their partition coefficient triggering aqueous to organic phase transfer, which indicated their potential to partition into cell membranes upon application of an external stimulus. Fluorescence-based assays indicated that the LCST transition did not induce lysis of model phospholipid vesicles but did promote fusion, as confirmed by dynamic light scattering. Membrane perturbation assays and linear dichroism spectroscopy investigations suggest that POEGMAs above their transition temperatures can interact with, or insert into, membranes. These findings will help develop the application of responsive polymers in drug delivery. The interactions of thermoresponsive poly[oligo(ethyleneglycol)methacrylates] with phospholipid bilayers as the polymers are heated above their lower critical solution temperature (LCST) are studied. Above the LCST, the polymers are lipophilic and can, therefore, insert in lipid bilayers, as probed by a series of complementary assays. This provides insight into the role of "smart" polymers in biotechnological applications. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
|Item Type:||Journal Article|
|Divisions:||Faculty of Science > Chemistry|
|Journal or Publication Title:||Macromolecular Rapid Communications|
|Publisher:||Wiley - V C H Verlag GmbH & Co. KGaA|
|Date:||14 May 2012|
|Page Range:||pp. 779-784|
|Access rights to Published version:||Restricted or Subscription Access|
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