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Detergent-free incorporation of a seven-transmembrane receptor protein into nanosized bilayer lipodisq particles for functional and biophysical studies
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Orwick-Rydmark, Marcella, Lovett, Janet E., Graziadei, Andrea, Lindholm, Ljubica, Hicks, Matthew R. and Watts, Anthony. (2012) Detergent-free incorporation of a seven-transmembrane receptor protein into nanosized bilayer lipodisq particles for functional and biophysical studies. Nano Letters, Vol.12 (No.9). pp. 4687-4692. ISSN 1530-6984
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Official URL: http://dx.doi.org/10.1021/nl3020395
Abstract
SMA-Lipodisq nanoparticles, with one bacteriorhodopsin (bR) per 12 nm particle on average (protein/lipid molar ratio, 1:172), were prepared without the use of detergents. Using pulsed and continuous wave nitroxide spin label electron paramagnetic resonance, the structural and dynamic integrity of bR was retained when compared with data for bR obtained in the native membrane and in detergents and then with crystal data. This indicates the potential of Lipodisq nanoparticles as a useful membrane mimetic. © 2012 American Chemical Society.
| Item Type: | Journal Article |
|---|---|
| Divisions: | Faculty of Science > Chemistry |
| Journal or Publication Title: | Nano Letters |
| Publisher: | American Chemical Society |
| ISSN: | 1530-6984 |
| Date: | 2012 |
| Volume: | Vol.12 |
| Number: | No.9 |
| Page Range: | pp. 4687-4692 |
| Identification Number: | 10.1021/nl3020395 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/50323 |
Data sourced from Thomson Reuters' Web of Knowledge
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