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Probing bacterial-toxin inhibition with synthetic glycopolymers prepared by tandem post-polymerization modification : role of linker length and carbohydrate density
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Richards, Sarah-Jane, Jones, Mathew W., Hunaban, Mark, Haddleton, David M. and Gibson, Matthew I. (2012) Probing bacterial-toxin inhibition with synthetic glycopolymers prepared by tandem post-polymerization modification : role of linker length and carbohydrate density. Angewandte Chemie International Edition, Vol.51 (No.31). pp. 7812-7816. doi:10.1002/anie.201202945 ISSN 1433-7851.
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Official URL: http://dx.doi.org/10.1002/anie.201202945
Abstract
Probing the depths: A tandem post-polymerization modification strategy was used to systematically probe the multivalent inhibition of a bacterial toxin as a function of linker length (see scheme), carbohydrate density, and glycopolymer chain length. Guided by structural-biology information, the binding-pocket depth of the toxin was probed and used as a means to specifically improve inhibition of the toxin by the glycopolymer.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | Angewandte Chemie International Edition | ||||
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||
ISSN: | 1433-7851 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | Vol.51 | ||||
Number: | No.31 | ||||
Page Range: | pp. 7812-7816 | ||||
DOI: | 10.1002/anie.201202945 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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