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Novel tertiary amine oxide surfaces that resist non-specific protein adsorption

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Dilly, Suzanne J., Beecham, Matthew P., Brown, Steven P., Griffin, John M., Clark, Andrew J., Griffin, Craig D., Marshall, Jacqueline, Napier, R. (Richard), Taylor, Paul C. and Marsh, Andrew. (2006) Novel tertiary amine oxide surfaces that resist non-specific protein adsorption. Langmuir, Vol.22 (No.19). pp. 8144-8150. ISSN 1520-5827

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Official URL: http://dx.doi.org/10.1021/la060743j

Abstract

Novel surfaces derivatised with tertiary amine oxides have been prepared and tested for their ability to resist non-specific protein adsorption. The oxidation of tertiary amines supported on triazine units was carried out using m-cpba to give a format allowing conjugation of biologically active ligands alongside them. Adsorption to these surfaces was tested and compared with adsorption to a set of commercial and custom oligo- / polyethylene glycol (OEG/PEG) supports by challenging them with a protein display library presented on bacteriophage λ. The new class of amine oxide surfaces is found to equal or exceed the performance of the OEG/PEG supports in the prevention of non-specific binding.

Item Type:

Journal Article

Subjects:

Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology

Divisions:

Faculty of Science > Chemistry
Faculty of Science > Physics
Faculty of Science > Life Sciences (2010- ) > Warwick HRI (2004-2010)

Library of Congress Subject Headings (LCSH):

Proteins -- Absorption and adsorption, Amines

Journal or Publication Title:

Langmuir

Publisher:

American Chemical Society

ISSN:

1520-5827

Official Date:

2006

Dates:

Date	Event
2006	Published

Volume:

Vol.22

Number:

No.19

Number of Pages:

Page Range:

pp. 8144-8150

Identification Number:

10.1021/la060743j

Status:

Peer Reviewed

Publication Status:

Published

Access rights to Published version:

Restricted or Subscription Access

Funder:

Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC), Royal Society (Great Britain)

Grant number:

GR 88/EGM17690 (BBSRC)

References:

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