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Novel tertiary amine oxide surfaces that resist non-specific protein adsorption
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Dilly, Suzanne J., Beecham, Matthew P., Brown, Steven P., Griffin, John M., Clark, Andrew J., Griffin, Craig D., Marshall, Jacqueline, Napier, R. (Richard), Taylor, Paul C. and Marsh, Andrew (2006) Novel tertiary amine oxide surfaces that resist non-specific protein adsorption. Langmuir, Vol.22 (No.19). pp. 8144-8150. doi:10.1021/la060743j
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WRAOP_Marsh_ProteinResistantSurfacesLangmuir17-3-06.pdf - Submitted Version Embargoed item. Restricted access to Repository staff only Download (389Kb) |
Official URL: http://dx.doi.org/10.1021/la060743j
Abstract
Novel surfaces derivatised with tertiary amine oxides have been prepared and tested for their ability to resist non-specific protein adsorption. The oxidation of tertiary amines supported on triazine units was carried out using m-cpba to give a format allowing conjugation of biologically active ligands alongside them. Adsorption to these surfaces was tested and compared with adsorption to a set of commercial and custom oligo- / polyethylene glycol (OEG/PEG) supports by challenging them with a protein display library presented on bacteriophage λ. The new class of amine oxide surfaces is found to equal or exceed the performance of the OEG/PEG supports in the prevention of non-specific binding.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
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| Divisions: | Faculty of Science > Chemistry Faculty of Science > Physics Faculty of Science > Life Sciences (2010- ) > Warwick HRI (2004-2010) |
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| Library of Congress Subject Headings (LCSH): | Proteins -- Absorption and adsorption, Amines | ||||
| Journal or Publication Title: | Langmuir | ||||
| Publisher: | American Chemical Society | ||||
| ISSN: | 1520-5827 | ||||
| Official Date: | 2006 | ||||
| Dates: |
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| Volume: | Vol.22 | ||||
| Number: | No.19 | ||||
| Number of Pages: | 7 | ||||
| Page Range: | pp. 8144-8150 | ||||
| DOI: | 10.1021/la060743j | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC), Royal Society (Great Britain) | ||||
| Grant number: | GR 88/EGM17690 (BBSRC) |
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