Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Novel tertiary amine oxide surfaces that resist non-specific protein adsorption

Tools
- Tools
+ Tools

Dilly, Suzanne J., Beecham, Matthew P., Brown, Steven P., Griffin, John M., Clark, Andrew J., Griffin, Craig D., Marshall, Jacqueline, Napier, R. (Richard), Taylor, Paul C. and Marsh, Andrew (2006) Novel tertiary amine oxide surfaces that resist non-specific protein adsorption. Langmuir, Vol.22 (No.19). pp. 8144-8150. doi:10.1021/la060743j

[img] Text
WRAOP_Marsh_ProteinResistantSurfacesLangmuir17-3-06.pdf - Submitted Version
Embargoed item. Restricted access to Repository staff only

Download (389Kb)
Official URL: http://dx.doi.org/10.1021/la060743j

Request Changes to record.

Abstract

Novel surfaces derivatised with tertiary amine oxides have been prepared and tested for their ability to resist non-specific protein adsorption. The oxidation of tertiary amines supported on triazine units was carried out using m-cpba to give a format allowing conjugation of biologically active ligands alongside them. Adsorption to these surfaces was tested and compared with adsorption to a set of commercial and custom oligo- / polyethylene glycol (OEG/PEG) supports by challenging them with a protein display library presented on bacteriophage λ. The new class of amine oxide surfaces is found to equal or exceed the performance of the OEG/PEG supports in the prevention of non-specific binding.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science > Chemistry
Faculty of Science > Physics
Faculty of Science > Life Sciences (2010- ) > Warwick HRI (2004-2010)
Library of Congress Subject Headings (LCSH): Proteins -- Absorption and adsorption, Amines
Journal or Publication Title: Langmuir
Publisher: American Chemical Society
ISSN: 1520-5827
Official Date: 2006
Dates:
DateEvent
2006Published
Volume: Vol.22
Number: No.19
Number of Pages: 7
Page Range: pp. 8144-8150
DOI: 10.1021/la060743j
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC), Royal Society (Great Britain)
Grant number: GR 88/EGM17690 (BBSRC)

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us