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Spatiotemporal distribution of white matter lesions in relapsing-remitting and secondary progressive multiple sclerosis
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Filli, L., Hofstetter, L., Kuster, P., Traud, S., Mueller-Lenke, N., Naegelin, Y., Kappos, L., Gass, A., Sprenger, T., Nichols, Thomas E., Vrenken, H., Barkhof, F., Polman, C., Radue, E. -W., Borgwardt, S. J. and Bendfeldt, K. (2012) Spatiotemporal distribution of white matter lesions in relapsing-remitting and secondary progressive multiple sclerosis. Multiple Sclerosis Journal, Vol.18 (No.11). pp. 1577-1584. doi:10.1177/1352458512442756 ISSN 1352-4585.
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Official URL: http://dx.doi.org/10.1177/1352458512442756
Abstract
Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. MS lesions show a typical distribution pattern and primarily affect the white matter (WM) in the periventricular zone and in the centrum semiovale.
Objective: To track lesion development during disease progression, we compared the spatiotemporal distribution patterns of lesions in relapsing–remitting MS (RRMS) and secondary progressive MS (SPMS).
Methods: We used T1 and T2 weighted MR images of 209 RRMS and 62 SPMS patients acquired on two different 1.5 Tesla MR scanners in two clinical centers followed up for 25 (± 1.7) months. Both cross-sectional and longitudinal differences in lesion distribution between RRMS and SPMS patients were analyzed with lesion probability maps (LPMs) and permutation-based inference.
Results: MS lesions clustered around the lateral ventricles and in the centrum semiovale. Cross-sectionally, compared to RRMS patients, the SPMS patients showed a significantly higher regional probability of T1 hypointense lesions (p≤0.03) in the callosal body, the corticospinal tract, and other tracts adjacent to the lateral ventricles, but not of T2 lesions (peak probabilities were RRMS: T1 9%, T2 18%; SPMS: T1 21%, T2 27%). No longitudinal changes of regional T1 and T2 lesion volumes between baseline and follow-up scan were found.
Conclusion: The results suggest a particular vulnerability to neurodegeneration during disease progression in a number of WM tracts.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Statistics Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) |
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| Journal or Publication Title: | Multiple Sclerosis Journal | ||||
| Publisher: | Sage Publications Ltd. | ||||
| ISSN: | 1352-4585 | ||||
| Official Date: | 2012 | ||||
| Dates: |
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| Volume: | Vol.18 | ||||
| Number: | No.11 | ||||
| Page Range: | pp. 1577-1584 | ||||
| DOI: | 10.1177/1352458512442756 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published |
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