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Activation mechanisms for organometallic anticancer complexes
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Pizarro, Ana M., Habtemariam, Abraha and Sadler, P. J. (2010) Activation mechanisms for organometallic anticancer complexes. In: Medicinal organometallic chemistry. Topics in Organometallic Chemistry, Vol.32 . Springer-Verlag, Berlin ; New York, pp. 21-56. ISBN 9783642131844
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Official URL: http://webcat.warwick.ac.uk/record=b2336810~S1
Abstract
Organometallic complexes offer potential for design as anticancer drugs. They can act as inert scaffolds and specifically inhibit enzymes such as kinases, or as pro-drugs which undergo activation by various mechanisms. The activation of metallocenes, arene, alkyl or aryl complexes by hydrolysis, and metal- or ligand-based redox reactions is discussed.
| Item Type: | Book Item |
|---|---|
| Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Science > Chemistry |
| Library of Congress Subject Headings (LCSH): | Photochemistry, Organometallic compounds -- Therapeutic use, Antineoplastic agents, Pharmaceutical chemistry, Hydrolysis, Drug activation |
| Series Name: | Topics in Organometallic Chemistry |
| Journal or Publication Title: | MEDICINAL ORGANOMETALLIC CHEMISTRY |
| Publisher: | Springer-Verlag |
| Place of Publication: | Berlin ; New York |
| ISBN: | 9783642131844 |
| ISSN: | 1436-6002 |
| Book Title: | Medicinal organometallic chemistry |
| Editor: | Jaouen, Gérard and Metzler-Nolte, Nils |
| Date: | 2010 |
| Volume: | Vol.32 |
| Number of Pages: | 291 |
| Page Range: | pp. 21-56 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Related URLs: | |
| URI: | http://wrap.warwick.ac.uk/id/eprint/5069 |
Data sourced from Thomson Reuters' Web of Knowledge
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