Agoti, Charles N., Mbisa, Jean L., Bett, Ann, Medley, Graham, Nokes, D. James and Cane, Patricia (2010) Intrapatient variation of the respiratory syncytial virus attachment protein gene. Journal of Virology, Vol.84 (No.19). pp. 10425-10428. doi:10.1128/JVI.01181-10 ISSN 0022-538X.

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Abstract

Intrapatient variability of the attachment (G) protein gene of respiratory syncytial virus (RSV) was examined using both population and single-genome sequencing. Samples from three patients infected with a group B virus variant which has a 60-nucleotide duplication in the G protein gene were examined. These samples were chosen because occasional mixed sequence bases were observed. In a minority of RSV genomes from these patients considerable variability was found, including point mutations, insertions, and deletions. Of particular note, the deletion of the exact portion of the gene which had been duplicated in some isolates was observed in viral RNAs from two patients.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR355 Virology
Divisions:	Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Journal or Publication Title:	Journal of Virology
Publisher:	American Society for Microbiology
ISSN:	0022-538X
Official Date:	October 2010
Dates:	Date Event October 2010 Published
Volume:	Vol.84
Number:	No.19
Number of Pages:	4
Page Range:	pp. 10425-10428
DOI:	10.1128/JVI.01181-10
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Wellcome Trust
Grant number:	085882, 084663

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