pH-switchable polymer nanostructures for controlled release
Doncom, Kay E. B., Hansell, Claire F., Theato, Patrick and O'Reilly, Rachel K.. (2012) pH-switchable polymer nanostructures for controlled release. Polymer Chemistry, Vol.3 (No.10). pp. 3007-3015. ISSN 1759-9954Full text not available from this repository.
Official URL: http://dx.doi.org/10.1039/C2PY20545A
A diblock copolymer consisting of poly(methyl acrylate) (PMA) and poly(pentafluorophenyl acrylate) (PPFPA) was synthesized by RAFT polymerization methods. The PPFPA block was then substituted with N,N-diisopropylethylenediamine and the end group modified with one of two hydrophilic groups to form pH-responsive copolymers. The self-assembly properties of these polymers were investigated and shown by TEM and DLS to form micelles at acidic pH and vesicles at basic pH. The encapsulation and controlled release of a hydrophilic dye molecule, Rhodamine B, was demonstrated using fluorescence spectroscopy.
|Item Type:||Journal Article|
|Divisions:||Faculty of Science > Chemistry|
|Journal or Publication Title:||Polymer Chemistry|
|Publisher:||Royal Society of Chemistry|
|Page Range:||pp. 3007-3015|
|Access rights to Published version:||Restricted or Subscription Access|
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