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pH-switchable polymer nanostructures for controlled release
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Doncom, Kay E. B., Hansell, Claire F., Theato, Patrick and O'Reilly, Rachel K. (2012) pH-switchable polymer nanostructures for controlled release. Polymer Chemistry, Vol.3 (No.10). pp. 3007-3015. doi:10.1039/c2py20545a
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Official URL: http://dx.doi.org/10.1039/C2PY20545A
Abstract
A diblock copolymer consisting of poly(methyl acrylate) (PMA) and poly(pentafluorophenyl acrylate) (PPFPA) was synthesized by RAFT polymerization methods. The PPFPA block was then substituted with N,N-diisopropylethylenediamine and the end group modified with one of two hydrophilic groups to form pH-responsive copolymers. The self-assembly properties of these polymers were investigated and shown by TEM and DLS to form micelles at acidic pH and vesicles at basic pH. The encapsulation and controlled release of a hydrophilic dye molecule, Rhodamine B, was demonstrated using fluorescence spectroscopy.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Journal or Publication Title: | Polymer Chemistry | ||||
| Publisher: | Royal Society of Chemistry | ||||
| ISSN: | 1759-9954 | ||||
| Official Date: | 2012 | ||||
| Dates: |
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| Volume: | Vol.3 | ||||
| Number: | No.10 | ||||
| Page Range: | pp. 3007-3015 | ||||
| DOI: | 10.1039/c2py20545a | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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