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Sequence-specific synthesis of macromolecules using DNA-templated chemistry
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Milnes, Phillip J., McKee, Mireya L., Bath, Jonathan, Song, Lijiang, Stulz, Eugen, Turberfield, Andrew J. and O'Reilly, Rachel K.. (2012) Sequence-specific synthesis of macromolecules using DNA-templated chemistry. Chemical Communications, Vol.48 (No.45). pp. 5614-5616. ISSN 1359-7345
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Official URL: http://dx.doi.org/10.1039/C2CC31975F
Abstract
Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control.
| Item Type: | Journal Article |
|---|---|
| Divisions: | Faculty of Science > Chemistry |
| Journal or Publication Title: | Chemical Communications |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| Date: | 2012 |
| Volume: | Vol.48 |
| Number: | No.45 |
| Page Range: | pp. 5614-5616 |
| Identification Number: | 10.1039/c2cc31975f |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/50778 |
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