Wooldridge, Linda, Laugel, Bruno, Ekeruche, Julia, Clement, Mathew, Berg, Hugo van den, 1968-, Price, David A. and Sewell, Andrew K.. (2010) CD8 controls T cell cross-reactivity. Journal of Immunology, Vol.185 (No.8). pp. 4625-4632. ISSN 0022-1767

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Abstract

Estimates of human alpha beta TCR diversity suggest that there are <10(8) different Ag receptors in the naive T cell pool, a number that is dwarfed by the potential number of different antigenic peptide-MHC (pMHC) molecules that could be encountered. Consequently, an extremely high degree of cross-reactivity is essential for effective T cell immunity. Ag recognition by T cells is unique in that it involves a coreceptor that binds at a site distinct from the TCR to facilitate productive engagement of the pMHC. In this study, we show that the CD8 coreceptor controls T cell cross-reactivity for pMHCI Ags, thereby ensuring that the peripheral T cell repertoire is optimally poised to negotiate the competing demands of responsiveness in the face of danger and quiescence in the presence of self. The Journal of Immunology, 2010, 185: 4625-4632.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Divisions:	Faculty of Science > Mathematics Faculty of Science > Centre for Systems Biology
Journal or Publication Title:	Journal of Immunology
Publisher:	American Association of Immunologists
ISSN:	0022-1767
Date:	15 October 2010
Volume:	Vol.185
Number:	No.8
Number of Pages:	8
Page Range:	pp. 4625-4632
Identification Number:	10.4049/jimmunol.1001480
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Wellcome Trust, Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
Grant number:	BB/H001085/1 (BBSRC)
URI:	http://wrap.warwick.ac.uk/id/eprint/5078

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