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CD8 controls T cell cross-reactivity

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Wooldridge, L., Laugel, Bruno, Ekeruche, Julia, Clement, Mathew, Berg, Hugo van den, Price, D. A. and Sewell, Andrew K. (2010) CD8 controls T cell cross-reactivity. Journal of Immunology, Volume 185 (Number 8). pp. 4625-4632. doi:10.4049/jimmunol.1001480 ISSN 0022-1767.

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Official URL: http://dx.doi.org/10.4049/jimmunol.1001480

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Abstract

Estimates of human alpha beta TCR diversity suggest that there are <10(8) different Ag receptors in the naive T cell pool, a number that is dwarfed by the potential number of different antigenic peptide-MHC (pMHC) molecules that could be encountered. Consequently, an extremely high degree of cross-reactivity is essential for effective T cell immunity. Ag recognition by T cells is unique in that it involves a coreceptor that binds at a site distinct from the TCR to facilitate productive engagement of the pMHC. In this study, we show that the CD8 coreceptor controls T cell cross-reactivity for pMHCI Ags, thereby ensuring that the peripheral T cell repertoire is optimally poised to negotiate the competing demands of responsiveness in the face of danger and quiescence in the presence of self. The Journal of Immunology, 2010, 185: 4625-4632.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology > QR180 Immunology
Divisions: Faculty of Science, Engineering and Medicine > Science > Mathematics
Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre
Library of Congress Subject Headings (LCSH): T cells, Antigens -- Receptors, Ligand binding (Biochemistry), T cells -- Receptors
Journal or Publication Title: Journal of Immunology
Publisher: American Association of Immunologists
ISSN: 0022-1767
Official Date: 15 October 2010
Dates:
DateEvent
15 October 2010Published
Volume: Volume 185
Number: Number 8
Number of Pages: 8
Page Range: pp. 4625-4632
DOI: 10.4049/jimmunol.1001480
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Wellcome Trust (London, England), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
Grant number: BB/H001085/1 (BBSRC)
Version or Related Resource: Conference abstract: Ekeruche, J., et al. (2010). CD8 controls T cell cross-reactivity. In: Special Issue: Annual Congress of the British Society, 6-10 December, Liverpool, UK, Immunology, 131(S1), pp. 172-173. http://wrap.warwick.ac.uk/id/eprint/4562
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