Biomimetic radical polymerization via cooperative assembly of segregating templates
McHale, Ronan, Patterson, Joseph P., Zetterlund, Per B. and O'Reilly, Rachel K.. (2012) Biomimetic radical polymerization via cooperative assembly of segregating templates. Nature Chemistry, Vol.4 (No.6). pp. 491-497. ISSN 1755-4330Full text not available from this repository.
Official URL: http://dx.doi.org/10.1038/nchem.1331
Segregation and templating approaches have been honed by billions of years of evolution to direct many complex biological processes. Nature uses segregation to improve biochemical control by organizing reactants into defined, well-regulated environments, and the transfer of genetic information is a primary function of templating. The ribosome, wherein messenger RNA is translated into polypeptides, combines both techniques to allow for ideal biopolymer syntheses. Herein is presented a biomimetic segregation/templating approach to synthetic radical polymerization. Polymerization of a nucleobase-containing vinyl monomer in the presence of a complementary block copolymer template of low molecular weight yields high molecular weight (Mw up to ~400,000 g mol−1), extremely low polydispersity (≤1.08) daughter polymers. Control is attained by segregation of propagating radicals in discrete micelle cores (via cooperative assembly of dynamic template polymers). Significantly reduced bimolecular termination, combined with controlled propagation along a defined number of templates, ensures unprecedented control to afford well-defined high molecular weight polymers.
|Item Type:||Journal Article|
|Divisions:||Faculty of Science > Chemistry|
|Journal or Publication Title:||Nature Chemistry|
|Publisher:||Nature Publishing Group|
|Page Range:||pp. 491-497|
|Access rights to Published version:||Restricted or Subscription Access|
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