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Coherent peptide-mediated activity in a neuronal network controlled by subcellular signaling pathway: Experiments and modeling
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Zhang, Xuejuan, Leng, Gareth and Feng, Jianfeng (2010) Coherent peptide-mediated activity in a neuronal network controlled by subcellular signaling pathway: Experiments and modeling. In: 11th International Conference on Molecular Systems Biology (ICMSB09), Shanghai, People's Republic of China, June, 2009. Published in: Journal of Biotechnology, Vol.149 (No.3 Sp. Iss. SI). pp. 215-225. ISSN 0168-1656. doi:10.1016/j.jbiotec.2010.01.003
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Official URL: http://dx.doi.org/10.1016/j.jbiotec.2010.01.003
Abstract
Classically, information processing in the brain involves fast signaling mechanisms at a vast number of discrete sites, via spike-dependent neurotransmitter release at synapses. However, neurons also use a huge diversity of slower analog signaling mechanisms, these chemical signaling pathways, acting in a more global spatial scale and on a longer temporal scale, are closely related to social behaviors and emotion. How do these parallel signaling systems interact to give rise to coherent behavioral consequences? In this review, we consider the role of the neuropeptide oxytocin in the milk-ejection reflex as an example of how a complex neural network involving a peptidergic signaling pathway underlies the complex physiological behavior. (C) 2010 Elsevier B.V. All rights reserved.
| Item Type: | Conference Item (UNSPECIFIED) | ||||
|---|---|---|---|---|---|
| Subjects: | T Technology > TP Chemical technology | ||||
| Divisions: | Faculty of Science > Centre for Scientific Computing Faculty of Science > Computer Science |
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| Journal or Publication Title: | Journal of Biotechnology | ||||
| Publisher: | Elsevier Science BV | ||||
| ISSN: | 0168-1656 | ||||
| Official Date: | 1 September 2010 | ||||
| Dates: |
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| Volume: | Vol.149 | ||||
| Number: | No.3 Sp. Iss. SI | ||||
| Number of Pages: | 11 | ||||
| Page Range: | pp. 215-225 | ||||
| DOI: | 10.1016/j.jbiotec.2010.01.003 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | EPSRC, NSFC, FANEDD | ||||
| Grant number: | EP/E002331/1; 213219.X.Z.; 10971196, 10771155 | ||||
| Title of Event: | 11th International Conference on Molecular Systems Biology (ICMSB09) | ||||
| Type of Event: | Conference | ||||
| Location of Event: | Shanghai, People's Republic of China | ||||
| Date(s) of Event: | June, 2009 |
Data sourced from Thomson Reuters' Web of Knowledge
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