Hamer, Rizwan, Roche, Laura, Smillie, David, Harmer, Andrea, Mitchell, Daniel Anthony, Molostvov, Guerman, Lam, For T., Kashi, Habib, Tan, Lam Chin, Imray, C. (Chris), Fletcher, Simon, Briggs, David, Lowe, David, Zehnder, Daniel and Higgins, Rob. (2010) Soluble CD30 and Cd27 levels in patients undergoing HLA antibody-incompatible renal transplantation. Transplant Immunology, Vol.23 (No.4). pp. 161-165. ISSN 0966-3274

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Abstract

HLA antibody-incompatible transplantation has a higher risk of rejection when compared to standard renal transplantation. Soluble CD30 (sCD30) has been shown in many, but not all, studies to be a biomarker for risk of rejection in standard renal transplant recipients. We sought to define the value of sCD30 and soluble CD27 (sCD27) in patients receiving HLA antibody-incompatible transplants. Serum taken at different time points from 32 HLA antibody-incompatible transplant recipients was retrospectively assessed for sCD30 and sCD27 levels by enzyme-linked immunosorbent assay (ELISA). This was compared to episodes of acute rejection, post-transplant donor-specific antibody (DSA) levels and 12 month serum creatinine levels. No association was found between sCD27 and sCD30 levels and risk of acute rejection or DSA levels. Higher sCD30 levels at 4-6 weeks post-transplantation were associated with a higher serum creatinine at 12 months.

Conclusion patients undergoing HLA antibody-incompatible transplantation are at a high risk of rejection but neither sCD30 (unlike in standard transplantation) nor sCD27 was found to be a risk factor. High sCD30 levels measured at 4-6 weeks post-transplantation was associated with poorer graft function at one year. (C) 2010 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR180 Immunology R Medicine > RD Surgery
Divisions:	Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Transplant Immunology
Publisher:	Elsevier BV
ISSN:	0966-3274
Official Date:	August 2010
Volume:	Vol.23
Number:	No.4
Number of Pages:	5
Page Range:	pp. 161-165
Identification Number:	10.1016/j.trim.2010.06.004
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/5116

Data sourced from Thomson Reuters' Web of Knowledge

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