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Soluble CD30 and Cd27 levels in patients undergoing HLA antibody-incompatible renal transplantation
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Hamer, Rizwan, Roche, Laura, Smillie, David, Harmer, Andrea, Mitchell, Daniel A., Molostvov, Guerman, Lam, For T., Kashi, Habib, Tan, Lam Chin, Imray, C. (Chris), Fletcher, Simon, Briggs, David, Lowe, David Philip, Zehnder, Daniel and Higgins, Rob (2010) Soluble CD30 and Cd27 levels in patients undergoing HLA antibody-incompatible renal transplantation. Transplant Immunology, Vol.23 (No.4). pp. 161-165. doi:10.1016/j.trim.2010.06.004 ISSN 0966-3274.
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Official URL: http://dx.doi.org/10.1016/j.trim.2010.06.004
Abstract
HLA antibody-incompatible transplantation has a higher risk of rejection when compared to standard renal transplantation. Soluble CD30 (sCD30) has been shown in many, but not all, studies to be a biomarker for risk of rejection in standard renal transplant recipients. We sought to define the value of sCD30 and soluble CD27 (sCD27) in patients receiving HLA antibody-incompatible transplants. Serum taken at different time points from 32 HLA antibody-incompatible transplant recipients was retrospectively assessed for sCD30 and sCD27 levels by enzyme-linked immunosorbent assay (ELISA). This was compared to episodes of acute rejection, post-transplant donor-specific antibody (DSA) levels and 12 month serum creatinine levels. No association was found between sCD27 and sCD30 levels and risk of acute rejection or DSA levels. Higher sCD30 levels at 4-6 weeks post-transplantation were associated with a higher serum creatinine at 12 months.
Conclusion patients undergoing HLA antibody-incompatible transplantation are at a high risk of rejection but neither sCD30 (unlike in standard transplantation) nor sCD27 was found to be a risk factor. High sCD30 levels measured at 4-6 weeks post-transplantation was associated with poorer graft function at one year. (C) 2010 Elsevier B.V. All rights reserved.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine > RD Surgery |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Transplant Immunology | ||||
| Publisher: | Elsevier BV | ||||
| ISSN: | 0966-3274 | ||||
| Official Date: | August 2010 | ||||
| Dates: |
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| Volume: | Vol.23 | ||||
| Number: | No.4 | ||||
| Number of Pages: | 5 | ||||
| Page Range: | pp. 161-165 | ||||
| DOI: | 10.1016/j.trim.2010.06.004 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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