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The selectivity and specificity of autophagy in drosophila
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Nezis, I. P. (2012) The selectivity and specificity of autophagy in drosophila. Cells, Volume 1 (Number 3). pp. 248-262. doi:10.3390/cells1030248 ISSN 2073-4409.
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Official URL: http://dx.doi.org/10.3390/cells1030248
Abstract
Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a significant role in cellular homeostasis. Despite the initial belief that autophagy is a nonselective bulk process, there is growing evidence during the last years that sequestration and degradation of cellular material by autophagy can be accomplished in a selective and specific manner. Given the role of autophagy and selective autophagy in several disease related processes such as tumorigenesis, neurodegeneration and infections, it is very important to dissect the molecular mechanisms of selective autophagy, in the context of the system and the organism. An excellent genetically tractable model organism to study autophagy is Drosophila, which appears to have a highly conserved autophagic machinery compared with mammals. However, the mechanisms of selective autophagy in Drosophila have been largely unexplored. The aim of this review is to summarize recent discoveries about the selectivity of autophagy in Drosophila.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QL Zoology Q Science > QR Microbiology Q Science > QR Microbiology > QR180 Immunology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Cell death, Apoptosis, Drosophila | ||||||||
| Journal or Publication Title: | Cells | ||||||||
| Publisher: | MDPI AG | ||||||||
| ISSN: | 2073-4409 | ||||||||
| Official Date: | 29 June 2012 | ||||||||
| Dates: |
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| Volume: | Volume 1 | ||||||||
| Number: | Number 3 | ||||||||
| Page Range: | pp. 248-262 | ||||||||
| DOI: | 10.3390/cells1030248 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 28 July 2016 | ||||||||
| Date of first compliant Open Access: | 28 July 2016 | ||||||||
| Funder: | European Research Council (ERC) |
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