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p62 at the Interface of Autophagy, Oxidative Stress Signaling, and Cancer
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Nezis, I. P. and Stenmark, H. (Harald) (2012) p62 at the Interface of Autophagy, Oxidative Stress Signaling, and Cancer. Antioxidants & Redox Signaling, Vol. 17 (No. 5). pp. 786-793. doi:10.1089/ars.2011.4394 ISSN 1523-0864.
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Official URL: http://dx.doi.org/10.1089/ars.2011.4394
Abstract
Significance: Sequestosome 1 (p62/SQSTM1) is a multifunctional adapter protein implicated in selective autophagy, cell signaling pathways, and tumorigenesis. Recent Advances: Recent evidence has revealed that p62/SQSTM1 has a critical role in an oxidative stress response pathway by its direct interaction with the ubiquitin ligase adaptor Kelch-like ECH-associated protein 1 (KEAP1), which results in constitutive activation of the transcription factor NF-E2-related factor 2 (NRF2). Critical Issues: Both NRF2 and KEAP1 are frequently mutated in cancer. The findings just cited uncover a link between p62/SQSTM1, autophagy, and the KEAP1-NRF2 stress response pathway in tumorigenesis and shed light on the interplay between autophagy and cancer. Future Directions: Here, we review the mechanisms by which p62/SQSTM1 implements its multiple roles in the regulation of tumorigenesis with emphasis on the KEAP1-NRF2 stress response signaling pathway. Uncovering the molecular mechanisms of p62/SQSTM1 function in oxidative stress signaling might contribute to elucidating its role in tumorigenesis.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Antioxidants & Redox Signaling | ||||
Publisher: | Mary Ann Liebert | ||||
ISSN: | 1523-0864 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | Vol. 17 | ||||
Number: | No. 5 | ||||
Page Range: | pp. 786-793 | ||||
DOI: | 10.1089/ars.2011.4394 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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