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Molecular and spatial epidemiology of human campylobacteriosis : source association and genotype-related risk factors
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Mullner, P., Shadbolt, T., Collins-Emerson, J. M., Midwinter, A. C., Spencer, Simon E. F., Marshall, J., Carter, P. E., Campbell, D. M., Wilson, D. J., Hathaway, S., Pirie, R. and French, N. P. (2010) Molecular and spatial epidemiology of human campylobacteriosis : source association and genotype-related risk factors. Epidemiology and Infection, Vol.138 (No.10). pp. 1372-1383. doi:10.1017/S0950268809991579 ISSN 0950-2688.
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Official URL: http://dx.doi.org/10.1017/S0950268809991579
Abstract
The epidemiology of human campylobacteriosis is complex but in recent years understanding of this disease has advanced considerably. Despite being a major public health concern in many countries, the presence of multiple hosts, genotypes and transmission pathways has made it difficult to identify and quantify the determinants of human infection and disease. This has delayed the development of successful intervention programmes for this disease in many countries including New Zealand, a country with a comparatively high, yet until recently poorly understood, rate of notified disease. This study investigated the epidemiology of Campylobacter jejuni at the genotype-level over a 3-year period between 2005 and 2008 using multilocus sequence typing. By combining epidemiological surveillance and population genetics, a dominant, internationally rare strain of C. jejuni (ST474) was identified, and most human cases (65ยท7%) were found to be caused by only seven different genotypes. Source association of genotypes was used to identify risk factors at the genotype-level through multivariable logistic regression and a spatial model. Poultry-associated cases were more likely to be found in urban areas compared to rural areas. In particular young children in rural areas had a higher risk of infection with ruminant strains than their urban counterparts. These findings provide important information for the implementation of pathway-specific control strategies.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Statistics | ||||
Journal or Publication Title: | Epidemiology and Infection | ||||
Publisher: | Cambridge University Press | ||||
ISSN: | 0950-2688 | ||||
Official Date: | 2010 | ||||
Dates: |
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Volume: | Vol.138 | ||||
Number: | No.10 | ||||
Page Range: | pp. 1372-1383 | ||||
DOI: | 10.1017/S0950268809991579 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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