Al-Attas, Omar S., Al-Daghri, Nasser M., Alokail, Majed S., Alfadda, Assim, Bamakhramah, Ahmed, Sabico, Shaun, Pritlove, D. C., Harte, A. L. (Alison L.), Tripathi, G. (Gyanendra), McTernan, P. G. (Philip G.), Kumar, Sudhesh and Chrousos, George. (2010) Adiposity and insulin resistance correlate with telomere length in middle-aged Arabs : the influence of circulating adiponectin. European Journal of Endocrinology, Vol.163 (No.4). pp. 601-607. ISSN 0804-4643

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Abstract

Objective: Studies in obesity have implicated adipocytokines in the development of insulin resistance, which in turn may lead to accelerated aging. In this study, we determined associations of chromosomal telomere length (TL) to markers of obesity and insulin resistance in middle-aged adult male and female Arabs with and without diabetes mellitus type 2 (DMT2). Design and methods: One hundred and ninety-three non-diabetic and DMT2 subjects without complications (97 males and 96 females) participated in this cross-sectional study. Clinical data, as well as fasting blood samples, were collected. Serum glucose and lipid profile were determined using routine laboratory methods. Serum insulin, leptin, adiponectin, resistin, tumor necrosis factor-alpha, and PAI-1 were quantified using customized multiplex assay kits. High sensitive C-reactive protein (hsCRP) and angiotensin II (ANG II) were measured using ELISAs. Circulating leukocyte TL was examined by quantitative real-time PCR. Results: Circulating chromosomal leukocyte TL had significant inverse associations with body mass index (BMI), systolic blood pressure, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), low-density lipoprotein (LDL)- and total cholesterol, ANG II and hsCRP levels. Adiponectin, BMI, systolic blood pressure, and LDL cholesterol predicted 47% of the variance in TL (P<0.0001). HOMA-IR was the most significant predictor for TL in males, explaining 35% of the variance (P=0.01). In females, adiponectin accounted for 28% of the variance in TL (P=0.01). Conclusion: Obesity and insulin resistance are associated with chromosomal TL among adult Arabs. Evidence of causal relations needs further investigation. The positive association of adiponectin to TL has clinical implications as to the possible protective effects of this hormone from accelerated aging.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	European Journal of Endocrinology
Publisher:	BioScientifica Ltd.
ISSN:	0804-4643
Date:	October 2010
Volume:	Vol.163
Number:	No.4
Number of Pages:	7
Page Range:	pp. 601-607
Identification Number:	10.1530/EJE-10-0241
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	King Abdul-Aziz City for Science and Technology (KACST), Riyadh, Kingdom of Saudi Arabia, British Heart Foundation, Research Council, UK
URI:	http://wrap.warwick.ac.uk/id/eprint/5153

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