Miller, Michelle A., Dr., Kandala, Ngianga-Bakwin, Kumari, Meena, Marmot, Michael G. and Cappuccio, Francesco P.. (2010) Relationships between sleep duration and von Willebrand factor, factor VII, and fibrinogen Whitehall II study. Arteriosclerosis, Thrombosis, and Vascular Biology, Vol.30 (No.10). pp. 2032-2038. ISSN 1079-5642

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Abstract

Objective-To examine the relationship between sleep duration and hemostatic factors in a well-characterized cohort. Methods and Results-The relationship between self-reported sleep duration and von Willebrand factor (vWF), fibrinogen, and factor VII was examined in approximately 6400 individuals from the Whitehall II Study. The analysis was stratified by sex (interaction P < 0.001). After multiple adjustments, vWF levels were significantly higher in men with both short sleep duration (<= 6 hours per night; 1.05 [95% CI, 1.01 to 1.08] [data given as geometric mean]) and long sleep duration (>= 8 hours per night; 1.05 [95% CI, 1.02 to 1.08]) compared with those who slept 7 hours (P < 0.05 for both). In women, levels of vWF were significantly higher in individuals who slept 8 hours or longer (1.11 [95% CI, 1.06 to 1.16]) compared with 7 hours (P < 0.05). This difference was observed in premenopausal and postmenopausal women. In women, the association was nonlinear (P = 0.02), but not in men (P = 0.09). No statistically significant associations between sleep duration and fibrinogen or factor VII were observed. Conclusion-Men who slept for short and long durations had higher vWF levels. In women, there was a significant nonlinear association. The highest levels were observed in long sleepers, irrespective of menopausal status. No major associations between sleep and factor VII or fibrinogen were observed. Longitudinal studies are required to investigate causality. (Arterioscler Thromb Vasc Biol. 2010;30:2032-2038.)

Item Type:	Journal Article
Subjects:	R Medicine > RB Pathology R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher:	Lippincott Williams & Wilkins
ISSN:	1079-5642
Date:	October 2010
Volume:	Vol.30
Number:	No.10
Number of Pages:	7
Page Range:	pp. 2032-2038
Identification Number:	10.1161/ATVBAHA.110.206987
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Medical Research Council, British Heart Foundation, Health and Safety Executive, Department of Health, National Heart Lung and Blood Institute, National Institute on Aging, National Institutes of Health, Agency for Health Care Policy Research, John D. and Catherine T. MacArthur Foundation Research Networks on Successful Midlife Development and Socio-economic Status and Health
Grant number:	HL36310, AG13196, HS06516
URI:	http://wrap.warwick.ac.uk/id/eprint/5165

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