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The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1
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Weyand, Simone, Shimamura, Tatsuro, Beckstein, Oliver, Sansom, M. S. P. (Mark S. P.), Iwata, So, Henderson, P. J. F. (Peter J. F.) and Cameron, Alexander (2011) The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1. Journal of Synchrotron Radiation, Vol. 18 (No. 1). pp. 20-23. doi:10.1107/S0909049510032449 ISSN 0909-0495.
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Official URL: http://dx.doi.org/10.1107/S0909049510032449
Abstract
Secondary active transporters move molecules across cell membranes by coupling this process to the energetically favourable downhill movement of ions or protons along an electrochemical gradient. They function by the alternating access model of transport in which, through conformational changes, the substrate binding site alternately faces either side of the membrane. Owing to the difficulties in obtaining the crystal structure of a single transporter in different conformational states, relatively little structural information is known to explain how this process occurs. Here, the structure of the sodium-benzylhydantoin transporter, Mhp1, from Microbacterium liquefaciens, has been determined in three conformational states; from this a mechanism is proposed for switching from the outward-facing open conformation through an occluded structure to the inward-facing open state.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Journal of Synchrotron Radiation | ||||
Publisher: | International Union of Crystallography | ||||
ISSN: | 0909-0495 | ||||
Official Date: | 2011 | ||||
Dates: |
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Volume: | Vol. 18 | ||||
Number: | No. 1 | ||||
Page Range: | pp. 20-23 | ||||
DOI: | 10.1107/S0909049510032449 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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