HIV infection significantly reduces lipoprotein lipase which remains low after 6 months of antiretroviral therapy
Boothby, M., Umpleby, A.M., Shojaee-Moradie, F., Tomlinson, J. W., Gathercole, L. L., McGee, K. C. (Kirsty Claire), Das, S. and Shahmanesh, Mohsen. (2008) HIV infection significantly reduces lipoprotein lipase which remains low after 6 months of antiretroviral therapy. Journal of the International AIDS Society, Vol.1 .
WRAP_McGee_HIV_Infection_1758-2652-11-S1-P113.pdf - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Official URL: http://dx.doi.org/10.1186/1758-2652-11-S1-P113
Purpose of the study Fractional clearance rate of apolipoprotein B100-containing lipoproteins is reduced in HIV infection before and after antiretroviral (ARV) treatment . We compared lipoprotein lipase (LPL) activity and gene expression in HIV-positive subjects before and 6 months after ARV with HIV-negative controls. Methods Fasting blood post heparin total and hepatic lipase activity,adiponectin, leptin, insulin, glucose, and lipid measurementswere made in 32 HIV-infected and 15 HIVnegative controls. LPL was estimated by subtractinghepatic lipase from total lipase. Adiponectin, LPL andhormone sensitive lipase (HSL) gene expression weremeasured from iliac crest subcutaneous fat biopsies.Patients were tested before, and 6 months after randomisation to AZT/3TC (n = 15) or TDF/FTC (n = 17) with EFV.Between-group comparison was by Mann-Whitney andpaired samples by the Wilcoxon signed rank tests. Summary of results There were no differences in gender, ethnicity, baseline BMI, regional fat distribution (whole body DEXA) and visceral (VAT) and subcutaneous fat (SAT) measured by abdominal CT scans between controls and patients. Trunk fat/BMI ratio, VAT and VAT:SAT ratio significantly increased after 6-month ARV therapy (p = 0.01). There were no differences between groups in serum NEFA,HOMA and leptin levels. Selected other results are shown in Table 1. Conclusion Post heparin lipoprotein lipase activity is reduced in HIV and does not return to control levels after 6 months of ARV therapy. AZT-containing regimens are associated with a greater increase in LPL, LPL gene expression and plasma adiponectin than TDF.
|Item Type:||Journal Article|
|Subjects:||R Medicine > R Medicine (General)|
|Divisions:||Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health
Faculty of Medicine > Warwick Medical School
|Library of Congress Subject Headings (LCSH):||HIV infection, Lipoprotein lipase|
|Journal or Publication Title:||Journal of the International AIDS Society|
|Date:||10 November 2008|
|Access rights to Published version:||Open Access|
|Version or Related Resource:||from Ninth International Congress on Drug Therapy in HIV Infection Glasgow, UK. 9–13 November 2008. ; Abstract published: Boothby, M., et al. (2008). HIV infection significantly reduces lipoprotein lipase which remains low after 6 months of antiretroviral therapy. Antiviral Therapy, 13(8), A57. http://wrap.warwick.ac.uk/id/eprint/28743|
|References:||1. Shahmanesh M, et al.: Antiretroviral treatment reduces verylow- density lipoprotein and intermediate-density lipoprotein apolipoprotein B fractional catabolic rate in human immunodeficiency virus-infected patients with mild dyslipidemia. J Clin Endocrinol Metabol 2005, 90:755-60.|
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