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HIV infection significantly reduces lipoprotein lipase which remains low after 6 months of antiretroviral therapy
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Boothby, M., Umpleby, A.M., Shojaee-Moradie, F., Tomlinson, J. W., Gathercole, L. L., McGee, K. C. (Kirsty Claire), Das, S. and Shahmanesh, Mohsen (2008) HIV infection significantly reduces lipoprotein lipase which remains low after 6 months of antiretroviral therapy. Journal of the International AIDS Society, Vol.1 . doi:10.1186/1758-2652-11-S1-P113
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Official URL: http://dx.doi.org/10.1186/1758-2652-11-S1-P113
Abstract
Purpose of the study
Fractional clearance rate of apolipoprotein B100-containing
lipoproteins is reduced in HIV infection before and
after antiretroviral (ARV) treatment [1]. We compared
lipoprotein lipase (LPL) activity and gene expression in
HIV-positive subjects before and 6 months after ARV with
HIV-negative controls.
Methods
Fasting blood post heparin total and hepatic lipase activity,adiponectin, leptin, insulin, glucose, and lipid measurementswere made in 32 HIV-infected and 15 HIVnegative
controls. LPL was estimated by subtractinghepatic lipase from total lipase. Adiponectin, LPL andhormone sensitive lipase (HSL) gene expression weremeasured from iliac crest subcutaneous fat biopsies.Patients were tested before, and 6 months after randomisation to AZT/3TC (n = 15) or TDF/FTC (n = 17) with EFV.Between-group comparison was by Mann-Whitney andpaired samples by the Wilcoxon signed rank tests.
Summary of results
There were no differences in gender, ethnicity, baseline
BMI, regional fat distribution (whole body DEXA) and
visceral (VAT) and subcutaneous fat (SAT) measured by
abdominal CT scans between controls and patients. Trunk
fat/BMI ratio, VAT and VAT:SAT ratio significantly
increased after 6-month ARV therapy (p = 0.01). There
were no differences between groups in serum NEFA,HOMA and leptin levels. Selected other results are shown
in Table 1.
Conclusion
Post heparin lipoprotein lipase activity is reduced in HIV
and does not return to control levels after 6 months of
ARV therapy. AZT-containing regimens are associated
with a greater increase in LPL, LPL gene expression and
plasma adiponectin than TDF.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > R Medicine (General) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | HIV infection, Lipoprotein lipase | ||||
Journal or Publication Title: | Journal of the International AIDS Society | ||||
Publisher: | BioMed Central | ||||
Official Date: | 10 November 2008 | ||||
Dates: |
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Volume: | Vol.1 | ||||
DOI: | 10.1186/1758-2652-11-S1-P113 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Version or Related Resource: | from Ninth International Congress on Drug Therapy in HIV Infection Glasgow, UK. 9–13 November 2008. ; Abstract published: Boothby, M., et al. (2008). HIV infection significantly reduces lipoprotein lipase which remains low after 6 months of antiretroviral therapy. Antiviral Therapy, 13(8), A57. http://wrap.warwick.ac.uk/id/eprint/28743 | ||||
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