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Tricks of the trade used to accelerate high-resolution structure determination of membrane proteins
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Sonoda, Yo, Cameron, Alexander, Newstead, Simon, Omote, Hiroshi, Moriyama, Yoshinori, Kasahara, Michihiro, Iwata, So and Drew, David (2010) Tricks of the trade used to accelerate high-resolution structure determination of membrane proteins. FEBS Letters, Vol. 584 (No. 12). pp. 2539-2547. doi:10.1016/j.febslet.2010.04.015 ISSN 0014-5793.
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Official URL: http://dx.doi.org/10.1016/j.febslet.2010.04.015
Abstract
The rate at which X-ray structures of membrane proteins are solved is on a par with that of soluble proteins in the late 1970s. There are still many obstacles facing the membrane protein structural community. Recently, there have been several technical achievements in the field that have started to dramatically accelerate structural studies. Here, we summarize these so-called ‘tricks-of-the-trade’ and include case studies of several mammalian transporters.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | FEBS Letters | ||||
Publisher: | Elsevier BV | ||||
ISSN: | 0014-5793 | ||||
Official Date: | 2010 | ||||
Dates: |
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Volume: | Vol. 584 | ||||
Number: | No. 12 | ||||
Page Range: | pp. 2539-2547 | ||||
DOI: | 10.1016/j.febslet.2010.04.015 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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