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Smoking initiation is followed by the early acquisition of epigenetic change in cervical epithelium: a longitudinal study
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Ma, Y. T., Collins, S. I., Young, Lawrence S., Murray, Paul G. and Woodman, Ciaran B. J. (2011) Smoking initiation is followed by the early acquisition of epigenetic change in cervical epithelium: a longitudinal study. British Journal of Cancer, Vol.104 (No.9). pp. 1500-1504. doi:10.1038/bjc.2011.113 ISSN 0007-0920.
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Official URL: http://dx.doi.org/10.1038/bjc.2011.113
Abstract
background: To prove a causal link between an epigenetic change and an environmental or behavioural risk factor for a given disease, it is first necessary to show that the onset of exposure precedes the first detection of that epigenetic change in subjects who are still free of disease.
methods: Towards this end, a cohort of women aged 15–19 years, recruited soon after they first had sexual intercourse, were used to provide sequential observations on the relationship between cigarette smoking and the detection in cervical cytological samples of methylated forms of CDKN2A (p16) using nested methylation-specific polymerase chain reaction.
results: Among women who remained cytologically normal and who tested negative for human papillomavirus DNA in cervical smears during follow-up, those who first started to smoke during follow-up had an increased risk of acquiring CDKN2A methylation compared with never-smokers (odds ratio=3.67; 95% confidence interval 1.09–12.33; P=0.04).
conclusion: Smoking initiation is associated with the appearance of methylated forms of CDKN2A.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | British Journal of Cancer | ||||
| Publisher: | Nature Publishing Group | ||||
| ISSN: | 0007-0920 | ||||
| Official Date: | 26 April 2011 | ||||
| Dates: |
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| Volume: | Vol.104 | ||||
| Number: | No.9 | ||||
| Page Range: | pp. 1500-1504 | ||||
| DOI: | 10.1038/bjc.2011.113 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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