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Prognostic impact of tumour-infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma
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Schreck, Sabine, Friebel, Daniela, Buettner, Maike, Distel, Luitpold, Grabenbauer, Gerhard, Young, Lawrence S. and Niedobitek, Gerald. (2009) Prognostic impact of tumour-infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma. Hematological Oncology, Vol.27 (No.1). pp. 31-39. ISSN 0278-0232
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Official URL: http://dx.doi.org/10.1002/hon.878
Abstract
Classical Hodgkin Lymphoma (cHL) is morphologically characterized by a small number of tumour cells, Hodgkin and Reed–Sternberg (HRS) cells, surrounded by numerous tumour-infiltrating lymphocytes (TIL). The functional role of these TIL is still controversial. While generally considered to represent an anti-tumour immune response, TIL in cHL might result from the profoundly deregulated immunity of cHL patients. Eighty-seven cases of cHL were available to evaluate the prognostical significance of tumour-infiltrating cytotoxic T lymphocytes (CTL), T helper 1 (Th1) cells, T helper 2 (Th2) cells and regulatory T cells (Treg). We confirm that in cHL the microenvironment is dominated by Th2 cells and Treg and show that large numbers of Th2 cells are associated with significantly improved disease-free survival (p = 0.021) and event-free survival (p = 0.012). Furthermore, a high ratio of Treg over Th2 cells resulted in a significantly shortened disease-free survival (p = 0.025). These observations suggest that Treg may exert inhibitory effects on anti-tumour immune responses mediated through Th2 cells and that Th2 cells may be more important for effective anti-tumour immunity than anticipated.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Hematological Oncology | ||||
| Publisher: | John Wiley & Sons Ltd. | ||||
| ISSN: | 0278-0232 | ||||
| Official Date: | March 2009 | ||||
| Dates: |
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| Volume: | Vol.27 | ||||
| Number: | No.1 | ||||
| Page Range: | pp. 31-39 | ||||
| Identification Number: | 10.1002/hon.878 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| URI: | http://wrap.warwick.ac.uk/id/eprint/51867 |
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