The Library
The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype
Tools
Tools
Tools
Vockerodt, M., Morgan, S. L., Kuo, M., Wei, W., Chukwuma, M. B., Arrand, J. R. (John R.), Kube, D., Gordon, J., Young, Lawrence S., Woodman, Ciaran B. J. and Murray, Paul G. (2008) The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype. Journal of Pathology, Vol.216 (No.1). pp. 83-92. doi:10.1002/path.2384 ISSN 0022-3417.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1002/path.2384
Abstract
Although the latent membrane protein-1 (LMP1) of the Epstein–Barr virus (EBV) is believed to be important for the transformation of germinal centre (GC) B cells, the precise contribution of this viral oncogene to lymphoma development is poorly understood. In this study, we used a non-viral vector-based method to express LMP1 in primary human GC B cells. Gene expression profiling revealed that LMP1 induced in GC B cells transcriptional changes characteristic of Hodgkin's lymphoma cell lines. Strikingly, LMP1 down-regulated the expression of B-cell-specific genes including B-cell receptor components such as CD79A, CD79B, CD19, CD20, CD22, and BLNK. LMP1 also induced the expression of ID2, a negative regulator of B-cell differentiation. Our data suggest that in EBV-positive cases, LMP1 is likely to be a major contributor to the altered transcriptional pattern characteristic of Hodgkin/Reed–Sternberg cells, including the loss of B-cell identity.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Journal of Pathology | ||||
| Publisher: | John Wiley & Sons Ltd. | ||||
| ISSN: | 0022-3417 | ||||
| Official Date: | September 2008 | ||||
| Dates: |
|
||||
| Volume: | Vol.216 | ||||
| Number: | No.1 | ||||
| Page Range: | pp. 83-92 | ||||
| DOI: | 10.1002/path.2384 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
