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The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype
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Vockerodt, M., Morgan, S. L., Kuo, M., Wei, W., Chukwuma, M. B., Arrand, J. R. (John R.), Kube, D., Gordon, J., Young, Lawrence S., Woodman, Ciaran B. J. and Murray, Paul G. (2008) The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype. Journal of Pathology, Vol.216 (No.1). pp. 83-92. doi:10.1002/path.2384
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Official URL: http://dx.doi.org/10.1002/path.2384
Abstract
Although the latent membrane protein-1 (LMP1) of the Epstein–Barr virus (EBV) is believed to be important for the transformation of germinal centre (GC) B cells, the precise contribution of this viral oncogene to lymphoma development is poorly understood. In this study, we used a non-viral vector-based method to express LMP1 in primary human GC B cells. Gene expression profiling revealed that LMP1 induced in GC B cells transcriptional changes characteristic of Hodgkin's lymphoma cell lines. Strikingly, LMP1 down-regulated the expression of B-cell-specific genes including B-cell receptor components such as CD79A, CD79B, CD19, CD20, CD22, and BLNK. LMP1 also induced the expression of ID2, a negative regulator of B-cell differentiation. Our data suggest that in EBV-positive cases, LMP1 is likely to be a major contributor to the altered transcriptional pattern characteristic of Hodgkin/Reed–Sternberg cells, including the loss of B-cell identity.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Journal of Pathology | ||||
| Publisher: | John Wiley & Sons Ltd. | ||||
| ISSN: | 0022-3417 | ||||
| Official Date: | September 2008 | ||||
| Dates: |
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| Volume: | Vol.216 | ||||
| Number: | No.1 | ||||
| Page Range: | pp. 83-92 | ||||
| DOI: | 10.1002/path.2384 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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