Páez, Carlos J., Schulz, Peter A., Wilson, Neil R. and Roemer, Rudolf A.. (2012) Robust signatures in the current–voltage characteristics of DNA molecules oriented between two graphene nanoribbon electrodes. New Journal of Physics, Vol.14 (No.9). 093049. ISSN 1367-2630

Preview

Text WRAP_Roemer_1367-2630_14_9_093049.pdf - Published Version Download (1446Kb) | Preview

Abstract

In this work, we numerically calculate the electric current through three kinds of DNA sequences (telomeric, λ-DNA and p53-DNA) described by different heuristic models. A bias voltage is applied between two zigzag edged graphene contacts attached to the DNA segments, while a gate terminal modulates the conductance of the molecule. Calculation of the current is performed by integrating the transmission function (calculated using the lattice Green's function) over the range of energies allowed by the chemical potentials. We show that a telomeric DNA sequence, when treated as a quantum wire in the fully coherent low-temperature regime, works as an excellent semiconductor. Clear steps are apparent in the current–voltage curves of telomeric sequences and are present independent of length and sequence initialization at the contacts. We also find that the molecule–electrode coupling can drastically influence the magnitude of the current. The difference between telomeric DNA and other DNAs, such as λ-DNA and DNA for the tumour suppressor p53, is particularly visible in the length dependence of the current.

Item Type:	Journal Article
Subjects:	Q Science > QC Physics Q Science > QH Natural history > QH426 Genetics
Divisions:	Faculty of Science > Physics
Library of Congress Subject Headings (LCSH):	DNA -- Electric properties, DNA -- Mathematical models
Journal or Publication Title:	New Journal of Physics
Publisher:	IOP Publishing
ISSN:	1367-2630
Date:	2012
Volume:	Vol.14
Number:	No.9
Page Range:	093049
Identification Number:	10.1088/1367-2630/14/9/093049
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
References:	[1] Fink H-W and Sch¨onenberger C 1999 Electrical conduction through DNA molecules Nature 398 407–10 [2] Porath D, Bezryadin A, Vries S and Dekker C 2000 Direct measurement of electrical transport through DNA molecules Nature 403 635–8 [3] Genereux J C and Barton J K 2010 Mechanisms for DNA charge transport Chem. Rev. 110 1642–62 [4] Feldman A K, Steigerwald M L, Guo X and Nuckolls C 2008 Molecular electronic devices based on singlewalled carbon nanotube electrodes Acc. Chem. Res. 41 1731–41 [5] Guo X, Gorodetsky A A, Hone J, Barton J K and Nuckolls C 2008 Conductivity of a single DNA duplex bridging a carbon nanotube gap Nature Nanotechnol. 3 163 [6] Slinker J D, Muren N B, Renfrew S E and Barton J K 2011 DNA charge transport over 34 nm Nature Chem. 3 228–33 [7] Alberts B, Bray D, Lewis J, Raff M, Roberts K andWatson J 1994 Molecular Biology of the Cell (New York: Garland) [8] Leonard F and Talin A A 2011 Electrical contacts to one- and two-dimensional nanomaterials Nature Nanotechnol. 6 773–83 [9] Prins F, Barreiro A, Ruitenberg JW, Seldenthuis J S, Aliaga-Alcalde N, Vandersypen LMK and van der Zant H S J 2011 Room-temperature gating of molecular junctions using few-layer graphene nanogap electrodes Nano Lett. 11 4607–11 [10] Standley B, BaoW, Zhang H, Bruck J, Lau C N and BockrathM2008 Graphene-based atomic-scale switches Nano Lett. 8 3345–9 [11] Datta S 1999 Electronic Transport in Mesoscopic Systems (Cambridge: Cambridge University Press) [12] Ferry D K and Goodnick S M 1997 Transport in Nanostructures (Cambridge: Cambridge University Press) [13] Cuniberti G, Macia E, Rodriguez A and R¨omer R A 2007 Tight-binding modeling of charge migration in DNA devices Charge Migration in DNA: Perspectives from Physics, Chemistry and Biology ed T Chakraborty (Berlin: Springer) pp 1–21 [14] Li X-Q and Yan Y J 2001 Electrical transport through individual DNA molecules Appl. Phys. Lett. 79 2190–2 [15] Joe Y S, Lee S H and Hedin E R 2010 Electron transport through asymmetric DNA molecules Phys. Lett. A 374 2367–73 [16] Carvalho R C P, Lyra M L, de Moura F A B F and Dom´ınguez-Adame F 2011 Localization on a two-channel model with cross-correlated disorder J. Phys.: Condens. Matter 23 175304 [17] Klotsa D K, R¨omer R A and Turner M S 2005 Electronic transport in DNA Biophys. J. 89 2187–98 [18] Wells S A, Shih C-T and R¨omer R A 2009 Modelling charge transport in DNA using transfer matrices with diagonal terms Int. J. Mod. Phys. B 23 4138–49 [19] Bixon M and Jortner J 2001 Charge transport in DNA via thermally induced hopping J. Am. Chem. Soc. 123 12556–67 [20] Kubaˇr T and Elstner M 2010 Coarse-grained time-dependent density functional simulation of charge transfer in complex systems: application to hole transfer in dna J. Phys. Chem. B 114 11221–40 [21] Cuniberti G, Craco L, Porath D and Dekker C 2002 Backbone-induced semiconducting behavior in short DNA wires Phys. Rev. B 65 241314–4 [22] Rak J, Voityuk A A, Marquez A and R¨osch N 2002 The effect of pyrimidine bases on the hole-transfer coupling in DNA J. Phys. Chem. B 106 7919–26 [23] Chakraborty T (ed) 2007 Charge Migration in DNA: Perspectives from Physics, Chemistry and Biology (Berlin: Springer) [24] Berashevich J A and Chakraborty T 2007 Mutational hot spots in DNA: where biology meets physics Phys. Can. 63 103–7 [25] Shih C-T, Wells S A, Hsu C-L, Cheng Y-Y and R¨omer R A 2012 The interplay of mutations and electronic properties in disease-related genes Sci. Rep. 2 272 [26] Roche S 2003 Sequence dependent DNA-mediated conduction Phys. Rev. Lett. 91 108101–4 [27] L´opez Sancho M P, L´opez Sancho J M and Rubio J 1985 Highly convergent schemes for the calculation of bulk and surface Green-functions J. Phys. F: Met. Phys. 15 851–8 [28] Larsen N B, Biebuyck H, Delamarche E and Michel B 1997 Order in microcontact printed self-assembled monolayers J. Am. Chem. Soc. 119 3017–26 [29] Burdett J K 1984 From bonds to bands and molecules to solids Prog. Solid State Chem. 15 173–255 [30] Damle P, Rakshit T, Paulsson M and Datta S 2002 Current–voltage characteristics of molecular conductors: two versus three terminal IEEE Trans. Nanotechnol. 1 145–53 [31] Zakian V A 1995 Telomeres: beginning to understand the end Science 270 1601–7 [32] Fogg P C M, Allison H E, Saunders J R and McCarthy A J 2010 Bacteriophage lambda: a paradigm revisited J. Virol. 84 6876–9 [33] de Pablo P J, Moreno-Herrero F, Colchero J, G´omez Herrero J, Herrero P, Bar´o A M, Ordej´on P, Soler J M and Artacho E 2000 Absence of DC-conductivity in -DNA Phys. Rev. Lett. 85 4992–5 [34] Tran P, Alavi B and Gr¨uner G 2000 Charge transport along the -DNA double helix Phys. Rev. Lett. 85 1564–7 [35] Shih C-T, Roche S and R¨omer R A 2008 Point-mutation effects on charge-transport properties of the tumorsuppressor gene p53 Phys. Rev. Lett. 100 018105 [36] Sherr C J 2004 Principles of tumor suppression Cell 116 235 [37] Tubbs J L and Tainer J A 2011 P53 conformational switching for selectivity may reveal a general solution for specific DNA binding EMBO J. 30 2099–2100 [38] Kitayner M, Rozenberg H, Rohs R, Suad O, Rabinovich D, Honig B and Shakked Z 2010 Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs Nature Struct. Mol. Biol. 17 423–9 [39] Cuniberti G, Craco L, Porath D and Dekker C 2002 Backbone-induced semiconducting behavior in short DNA wires Phys. Rev. B 65 241314 [40] Roy S, Vedala H, Roy A D, Kim D-H, Doud M, Mathee K, Shin H-K, Shimamoto N, Prasad V and Choi W 2008 Direct electrical measurements on single-molecule genomic DNA using single-walled carbon nanotubes Nano Lett. 8 26–30 [41] Castro Neto A H, Guinea F, Peres N M R, Novoselov K S and Geim A K 2009 The electronic properties of graphene Rev. Mod. Phys. 81 109 [42] Nakada K, Fujita M, Dresselhaus G and Dresselhaus M S 1996 Edge state in graphene ribbons: nanometer size effect and edge shape dependence Phys. Rev. B 54 17954–61
URI:	http://wrap.warwick.ac.uk/id/eprint/52013

Request changes to a record

Actions (login required)

View Item