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The natural history of respiratory syncytial virus in a birth cohort : the influence of age and previous infection on reinfection and disease

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Ohuma, E. O., Okiro, E. A., Ochola, R., Sande, C. J., Cane, Patricia, Medley, Graham, Bottomley, C. and Nokes, D. James (2012) The natural history of respiratory syncytial virus in a birth cohort : the influence of age and previous infection on reinfection and disease. American Journal of Epidemiology, Vol.176 (No.9). pp. 794-802. doi:10.1093/aje/kws257

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Official URL: http://dx.doi.org/10.1093/aje/kws257

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Abstract

This study aimed to quantify the effect of age, time since last infection, and infection history on the rate of respiratory syncytial virus infection and the effect of age and infection history on the risk of respiratory syncytial virus disease. A birth cohort of 635 children in Kilifi, Kenya, was monitored for respiratory syncytial virus infections from January 31, 2002, to April 22, 2005. Predictors of infection were examined by Cox regression and disease risk by binomial regression. A total of 598 respiratory syncytial virus infections were identified (411 primary, 187 repeat), with 409 determined by antigen assay and 189 by antibody alone (using a “most pragmatic” serologic definition). The incidence decreased by 70% following a primary infection (adjusted hazard ratio = 0.30, 95% confidence interval: 0.21, 0.42; P < 0.001) and by 59% following a secondary infection (hazard ratio = 0.41, 95% confidence interval: 0.22, 0.73; P = 0.003), for a period lasting 6 months. Relative to the age group <6 months, all ages exhibited a higher incidence of infection. A lower risk of severe disease following infection was independently associated with increasing age (P < 0.001) but not reinfection. In conclusion, observed respiratory syncytial virus incidence was lowest in the first 6 months of life, immunity to reinfection was partial and short lived, and disease risk was age related.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Respiratory syncytial virus -- Kenya
Journal or Publication Title: American Journal of Epidemiology
Publisher: Oxford University Press
ISSN: 0002-9262
Official Date: 2012
Dates:
DateEvent
2012Published
Date of first compliant deposit: 23 December 2015
Volume: Vol.176
Number: No.9
Page Range: pp. 794-802
DOI: 10.1093/aje/kws257
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Wellcome Trust (London, England)
Grant number: 061584 (WT), 076278 (WT)

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