Ohuma, E. O., Okiro, E. A., Ochola, R., Sande, C. J., Cane, Patricia, Medley, Graham, Bottomley, C. and Nokes, D. James. (2012) The natural history of respiratory syncytial virus in a birth cohort : the influence of age and previous infection on reinfection and disease. American Journal of Epidemiology, Vol.176 (No.9). pp. 794-802. ISSN 0002-9262

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Abstract

This study aimed to quantify the effect of age, time since last infection, and infection history on the rate of respiratory syncytial virus infection and the effect of age and infection history on the risk of respiratory syncytial virus disease. A birth cohort of 635 children in Kilifi, Kenya, was monitored for respiratory syncytial virus infections from January 31, 2002, to April 22, 2005. Predictors of infection were examined by Cox regression and disease risk by binomial regression. A total of 598 respiratory syncytial virus infections were identified (411 primary, 187 repeat), with 409 determined by antigen assay and 189 by antibody alone (using a “most pragmatic” serologic definition). The incidence decreased by 70% following a primary infection (adjusted hazard ratio = 0.30, 95% confidence interval: 0.21, 0.42; P < 0.001) and by 59% following a secondary infection (hazard ratio = 0.41, 95% confidence interval: 0.22, 0.73; P = 0.003), for a period lasting 6 months. Relative to the age group <6 months, all ages exhibited a higher incidence of infection. A lower risk of severe disease following infection was independently associated with increasing age (P < 0.001) but not reinfection. In conclusion, observed respiratory syncytial virus incidence was lowest in the first 6 months of life, immunity to reinfection was partial and short lived, and disease risk was age related.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH):	Respiratory syncytial virus -- Kenya
Journal or Publication Title:	American Journal of Epidemiology
Publisher:	Oxford University Press
ISSN:	0002-9262
Date:	2012
Volume:	Vol.176
Number:	No.9
Page Range:	pp. 794-802
Identification Number:	10.1093/aje/kws257
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Wellcome Trust (London, England)
Grant number:	061584 (WT), 076278 (WT)
References:	1. Nair H, Nokes DJ, Gessner BD, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010;375(9725):1545–1555. 2. Berkley JA. Viral etiology of severe pneumonia among Kenyan infants and children. JAMA. 2010;303(20): 2051–2057. 3. Zlateva KT, Vijgen L, Dekeersmaeker N, et al. Subgroup prevalence and genotype circulation patterns of human respiratory syncytial virus in Belgium during ten successive epidemic seasons. J Clin Microbiol. 2007;45(9):3022–3030. 4. Waris M. Pattern of respiratory syncytial virus epidemics in Finland: two-year cycles with alternating prevalence of groups A and B. J Infect Dis. 1991;163(3):464–469. 5. Mlinaric-Galinovic G, Welliver R, Vilibic-Cavlek T, et al. The biennial cycle of respiratory syncytial virus outbreaks in Croatia. Virol J. 2008;5:18. (doi:10.1186/1743-422X-5-18). 6. Glezen WP, Taber LH, Frank AL, et al. Risk of primary infection and reinfection with respiratory syncytial virus. Am J Dis Child. 1986;140(6):543–546. 7. Henderson FW, Collier AM, Clyde WA, et al. Respiratorysyncytial- virus infections, reinfections and immunity. N Engl J Med. 1979;300(10):530–534. 8. Hall CB, Geiman JM, Biggar R, et al. Respiratory syncytial virus infections within families. N Engl J Med. 1976;294(8): 414–419. 9. Chanock RM. Respiratory syncytial virus. J Am Med Assoc. 1961;176(8):647–667. 10. Nokes DJ, Okiro EA, Ngama M, et al. Respiratory syncytial virus infection and disease in infants and young children observed from birth in Kilifi District, Kenya. Clin Infect Dis. 2008;46(1):50–57. 11. Nokes DJ, Ngama M, Bett A, et al. Incidence and severity of respiratory syncytial virus pneumonia in rural Kenyan children identified through hospital surveillance. Clin Infect Dis. 2009;49(9):1341–1349. 12. White LJ, Waris M, Cane PA, et al. The transmission dynamics of groups A and B human respiratory syncytial virus (hRSV) in England & Wales and Finland: seasonality and cross-protection. Epidemiol Infect. 2005;133(2):279–289. 13. Weber A, Weber M, Milligan P. Modeling epidemics caused by respiratory syncytial virus (RSV). Math Biosci. 2001; 172(2):95–113. 14. White LJ, Mandl JN, Gomes MG, et al. Understanding the transmission dynamics of respiratory syncytial virus using multiple time series and nested models. Math Biosci. 2007;209(1):222–239. 15. Monto AS, Lim SK. The Tecumseh study of respiratory illness. Am J Epidemiol. 1971;94(3):290–301. 16. Cox MJ, Azevedo RS, Cane PA, et al. Seroepidemiological study of respiratory syncytial virus in Sao Paulo state, Brazil. J Med Virol. 1998;55(3):234–239. 17. Fletcher JN, Smyth RL, Thomas HM, et al. Respiratory syncytial virus genotypes and disease severity among children in hospital. Arch Dis Child. 1997;77(6):508–511. 18. Ochola R, Sande C, Fegan G, et al. The level and duration of RSV-specific maternal IgG in infants in Kilifi Kenya. PLoS One. 2009;4(12):e8088. (doi:10.1371/journal.pone.0008088). 19. Nokes DJ, Okiro EA, Ngama M, et al. Respiratory syncytial virus epidemiology in a birth cohort from Kilifi District, Kenya: infection during the first year of life. J Infect Dis. 2004;190(10):1828–1832. 20. Okiro EA, Sande C, Mutunga M, et al. Identifying infections with respiratory syncytial virus by using specific immunoglobulin G (IgG) and IgA enzyme-linked immunosorbent assays with oral-fluid samples. J Clin Microbiol. 2008;46(5):1659–1662. 21. Murphy BR, Graham BS, Prince GA, et al. Serum and nasalwash immunoglobulin G and A antibody response of infants and children to respiratory syncytial virus F and G glycoproteins following primary infection. J Clin Microbiol. 1986;23(6):1009–1014. 22. Welliver RC, Kaul TN, Putnam TI, et al. The antibody response to primary and secondary infection with respiratory syncytial virus: kinetics of class-specific responses. J Pediatr. 1980;96(5):808–813. 23. Okiro EA, Ngama M, Bett A, et al. Factors associated with increased risk of progression to respiratory syncytial virusassociated pneumonia in young Kenyan children. Trop Med Int Health. 2008;13(7):914–926. 24. Okiro EA. Transmission Dynamics of Respiratory Syncytial Virus Within the Household and in the Community [dissertation]. Milton Keynes, United Kingdom: Open University; 2007. 25. Ochola R. Passive and Acquired Immunity to Respiratory Syncytial Virus in Young Children in Rural Kenya [dissertation]. Milton Keynes, United Kingdom: Open University; 2007. 26. Ministry of Finance and Planning. Analytical Report on Population Projections. Vol. VIII. Nairobi, Kenya: Central Bureau of Statistics, Government of Kenya; 2002. 27. Scott PD, Ochola R, Sande C, et al. Comparison of strainspecific antibody responses during primary and secondary infections with respiratory syncytial virus. J Med Virol. 2007;79(12):1943–1950. 28. Cane PA, Thomas HM, Simpson AF, et al. Analysis of the human serological immune response to a variable region of the attachment (G) protein of respiratory syncytial virus during primary infection. J Med Virol. 1996;48(3):253–261. 29. Cox DR. Regression models and life-tables. J R Stat Soc Ser B (Methodological). 1972;34(2):187–220. 30. Rogers WH. Regression standard errors in clustered samples. Stata Tech Bull. 1993;13:19–23. 31. Moulton LH, Dibley MJ. Multivariate time-to-event models for studies of recurrent childhood diseases. Int J Epidemiol. 1997;26(6):1334–1339. 32. 332.McIntosh K, Masters HB, Orr I, et al. The immunologic response to infection with respiratory syncytial virus in infants. J Infect Dis. 1978;138(1):24–32. 33. Murphy BR, Alling DW, Snyder MH, et al. Effect of age and preexisting antibody on serum antibody response of infants and children to the F and G glycoproteins during respiratory syncytial virus infection. J Clin Microbiol. 1986; 24(5):894–898. 34. Brandenburg AH, Groen J, Steensel-Moll HA, et al. Respiratory syncytial virus specific serum antibodies in infants under six months of age: limited serological response upon infection. J Med Virol. 1997;52(1):97–104. 35. Parrott RH, Kim HW, Arrobio JO, et al. Epidemiology of respiratory syncytial virus infection in Washington, DC. Am J Epidemiol. 1973;98(4):289–300. 36. Hall CB, Douglas RG Jr, Geiman JM. Respiratory syncytial virus infections in infants: quantitation and duration of shedding. J Pediatr. 1976;89(1):11–15. 37. Glezen WP. Effect of maternal antibodies on the infant immune response. Vaccine. 2003;21(24):3389–3392.
URI:	http://wrap.warwick.ac.uk/id/eprint/52039

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