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Molecular aspects of implantation failure

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Koot, Y.E.M., Teklenburg, G., Salker, M.S., Brosens, Jan J. and Macklon, N.S. (2012) Molecular aspects of implantation failure. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol.1822 (No.12). pp. 1943-1950. doi:10.1016/j.bbadis.2012.05.017 ISSN 0925-4439.

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Official URL: http://dx.doi.org/10.1016/j.bbadis.2012.05.017

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Abstract

Despite expanding global experience with advanced reproductive technologies, the majority of IVF attempts do not result in a successful pregnancy, foremost as a result of implantation failure. The process of embryo implantation, a remarkably dynamic and precisely controlled molecular and cellular event, appears inefficient in humans and is poorly understood. However, insights gained from clinical implantation failure, early pregnancy loss, and emerging techologies that enable molecular interrogation of endometrial-embryo interactions are unravelling this major limiting step in human reproduction. We review current molecular concepts thought to underlie implantation failure, consider the contribution of embryonic and endometrial factors, and discuss the clinical value of putative markers of impaired endometrial receptivity. Finally we highlight the nature of the dialogue between the maternal endometrium and the implanting embryo and discuss the concept of natural embryo selection. This article is part of a Special Issue entitled: Molecular Genetics of Human Reproductive Failure. © 2012 Elsevier B.V.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016)
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
ISSN: 0925-4439
Official Date: December 2012
Dates:
DateEvent
December 2012Published
Volume: Vol.1822
Number: No.12
Page Range: pp. 1943-1950
DOI: 10.1016/j.bbadis.2012.05.017
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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