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Molecular aspects of implantation failure
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Koot, Y.E.M., Teklenburg, G., Salker, M.S., Brosens, Jan J. and Macklon, N.S. (2012) Molecular aspects of implantation failure. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol.1822 (No.12). pp. 1943-1950. doi:10.1016/j.bbadis.2012.05.017 ISSN 0925-4439.
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Official URL: http://dx.doi.org/10.1016/j.bbadis.2012.05.017
Abstract
Despite expanding global experience with advanced reproductive technologies, the majority of IVF attempts do not result in a successful pregnancy, foremost as a result of implantation failure. The process of embryo implantation, a remarkably dynamic and precisely controlled molecular and cellular event, appears inefficient in humans and is poorly understood. However, insights gained from clinical implantation failure, early pregnancy loss, and emerging techologies that enable molecular interrogation of endometrial-embryo interactions are unravelling this major limiting step in human reproduction. We review current molecular concepts thought to underlie implantation failure, consider the contribution of embryonic and endometrial factors, and discuss the clinical value of putative markers of impaired endometrial receptivity. Finally we highlight the nature of the dialogue between the maternal endometrium and the implanting embryo and discuss the concept of natural embryo selection. This article is part of a Special Issue entitled: Molecular Genetics of Human Reproductive Failure. © 2012 Elsevier B.V.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | ||||
| Publisher: | Elsevier BV | ||||
| ISSN: | 0925-4439 | ||||
| Official Date: | December 2012 | ||||
| Dates: |
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| Volume: | Vol.1822 | ||||
| Number: | No.12 | ||||
| Page Range: | pp. 1943-1950 | ||||
| DOI: | 10.1016/j.bbadis.2012.05.017 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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