Guell, Aleix G., Meadows, Katherine E., Unwin, Patrick R. and Macpherson, Julie V. (2010) Trace voltammetric detection of serotonin at carbon electrodes : comparison of glassy carbon, boron doped diamond and carbon nanotube network electrodes. Physical Chemistry Chemical Physics, Vol.12 (No.34). pp. 10108-10114. doi:10.1039/c0cp00675k

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Abstract

The characteristics of three different carbon electrodes, glassy carbon (GC), oxygen-terminated polycrystalline boron-doped diamond (pBDD) and "pristine" carbon nanotube networks (CNTN) as voltammetric sensors for detection of the neurotransmitter serotonin have been investigated. For each electrode, detection sensitivity was determined using cyclic voltammetry (CV), a technique often used to provide information on chemical identity in electrochemical assays. The CNTN electrodes were found to exhibit background current densities ca. two orders of magnitude smaller than the GC electrode and ca. twenty times smaller than pBDD, as a consequence of their "pristine" low capacitance and low surface coverage. This was a major factor in determining serotonin detection limits from CV, of 10 nM for the CNTN electrode, 500 nM for pBDD and 2 mu M for GC. The two most sensitive electrodes (CNTN and pBDD) were further investigated in terms of resistance to electrode fouling. CV analysis showed that fouling was less on the pBDD electrode compared to the CNTN and, furthemore, for the case of pBDD could be significantly minimised by careful selection of the CV potential limits, in particular by scanning the electrode potential to suitably cathodic values after oxidation of the serotonin.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry Q Science > QC Physics
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Voltammetry, Electrodes, Carbon, Serotonin, Nanotubes
Journal or Publication Title:	Physical Chemistry Chemical Physics
Publisher:	Royal Society of Chemistry
ISSN:	1463-9076
Official Date:	September 2010
Dates:	Date Event September 2010 Published
Volume:	Vol.12
Number:	No.34
Number of Pages:	7
Page Range:	pp. 10108-10114
DOI:	10.1039/c0cp00675k
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Seventh Framework Programme (European Commission) (FP7), University of Warwick. MOAC Doctoral Training Centre, Engineering and Physical Sciences Research Council (EPSRC), Advantage West Midlands (AWM), European Regional Development Fund (ERDF)
Grant number:	236885 (FP7), EP/H023909/1 (EPSRC)

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