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Trace voltammetric detection of serotonin at carbon electrodes : comparison of glassy carbon, boron doped diamond and carbon nanotube network electrodes
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Guell, Aleix G., Meadows, Katherine E., Unwin, Patrick R. and Macpherson, Julie V. (2010) Trace voltammetric detection of serotonin at carbon electrodes : comparison of glassy carbon, boron doped diamond and carbon nanotube network electrodes. Physical Chemistry Chemical Physics, Vol.12 (No.34). pp. 10108-10114. doi:10.1039/c0cp00675k ISSN 1463-9076.
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Official URL: http://dx.doi.org/10.1039/c0cp00675k
Abstract
The characteristics of three different carbon electrodes, glassy carbon (GC), oxygen-terminated polycrystalline boron-doped diamond (pBDD) and "pristine" carbon nanotube networks (CNTN) as voltammetric sensors for detection of the neurotransmitter serotonin have been investigated. For each electrode, detection sensitivity was determined using cyclic voltammetry (CV), a technique often used to provide information on chemical identity in electrochemical assays. The CNTN electrodes were found to exhibit background current densities ca. two orders of magnitude smaller than the GC electrode and ca. twenty times smaller than pBDD, as a consequence of their "pristine" low capacitance and low surface coverage. This was a major factor in determining serotonin detection limits from CV, of 10 nM for the CNTN electrode, 500 nM for pBDD and 2 mu M for GC. The two most sensitive electrodes (CNTN and pBDD) were further investigated in terms of resistance to electrode fouling. CV analysis showed that fouling was less on the pBDD electrode compared to the CNTN and, furthemore, for the case of pBDD could be significantly minimised by careful selection of the CV potential limits, in particular by scanning the electrode potential to suitably cathodic values after oxidation of the serotonin.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry Q Science > QC Physics |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Voltammetry, Electrodes, Carbon, Serotonin, Nanotubes | ||||
Journal or Publication Title: | Physical Chemistry Chemical Physics | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 1463-9076 | ||||
Official Date: | September 2010 | ||||
Dates: |
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Volume: | Vol.12 | ||||
Number: | No.34 | ||||
Number of Pages: | 7 | ||||
Page Range: | pp. 10108-10114 | ||||
DOI: | 10.1039/c0cp00675k | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Seventh Framework Programme (European Commission) (FP7), University of Warwick. MOAC Doctoral Training Centre, Engineering and Physical Sciences Research Council (EPSRC), Advantage West Midlands (AWM), European Regional Development Fund (ERDF) | ||||
Grant number: | 236885 (FP7), EP/H023909/1 (EPSRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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