The Library
Is the higher risk of cardiovascular disease amongst South Asian populations linked to abnormalities of haemoglobin? A preliminary case control study
Tools
Patel, Jeetesh V., Chackathayil, Julia, Gammon, Brian, Tracey, Inessa, Lovick, Adam, Gill, Paramjit, Banerjee, Amitava, Scarff, Charlotte A., Scrivens, James H., Lip, Gregory Y. H. and Hughes, E. (2012) Is the higher risk of cardiovascular disease amongst South Asian populations linked to abnormalities of haemoglobin? A preliminary case control study. Atherosclerosis . doi:10.1016/j.atherosclerosis.2012.09.017 ISSN 0021-9150.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.atherosclerosis.2012.0...
Abstract
The elevated burden of cardiovascular disease (CVD) amongst South Asian populations is a complex and multi-factorial phenomenon. South Asians evolved from environments where malaria was endemic, and while haemoglobin disorders frequent this group, a link to CVD has not been described. Using a case–control feasibility study, haemoglobin abnormalities identified by mass spectrometry were compared between South Asian patients with CVD (n = 72) and non-CVD controls (n = 84). Carotid-artery intima media thickness (CIMT) was used as a marker of vascular damage. Ultracentrifugation was used to separate lipoprotein subfractions, which were analysed for iron.
Haemoglobin anomalies were more frequent for CVD patients than controls (34.7% vs. 14.3%, P < 0.001), as were subfractionated lipoprotein concentrations of iron (P < 0.001). Patients with haemoglobin disorders had greater CIMT (0.75 vs. 0.65 mm, P = 0.008), and lower HDL cholesterol (0.78 vs. 1.03 mmol/l, P = 0.003). These preliminary data sugg
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Atherosclerosis | ||||
Publisher: | Elsevier Ireland Ltd. | ||||
ISSN: | 0021-9150 | ||||
Official Date: | 2012 | ||||
Dates: |
|
||||
DOI: | 10.1016/j.atherosclerosis.2012.09.017 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Description: | online ahead of print |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |