Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Toponome imaging system : multiplex biomarkers in oncology

Tools
- Tools
+ Tools

Evans, Robert G., Naidu, Babu, Rajpoot, Nasir M. (Nasir Mahmood), Epstein, D. B. A. and Khan, Michael (2012) Toponome imaging system : multiplex biomarkers in oncology. Trends in Molecular Medicine, Vol.18 (No.12). pp. 723-731. doi:10.1016/j.molmed.2012.10.003

Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1016/j.molmed.2012.10.003

Request Changes to record.

Abstract

Toponome imaging systems (TIS) can yield high-resolution subcellular colocalization images of multiple proteins within single cells and intact tissue sections, giving this technology significant potential for identifying multiplex biomarkers that simultaneously measure several aspects of a cell. The integral role of the microenvironment in malignant progression and the recently appreciated heterogeneity of cancer cells underscore the importance of characterizing complex molecular phenotypes and the large protein network structures of single cells within their preserved anatomical context. Here, we discuss the TIS technique and the potential for developing new sensitive and specific multiplex biomarkers for risk stratification and diagnosis, in addition to its utility for anticancer drug discovery by identifying ‘hub’ proteins that are essential regulators of protein networks.

Item Type: Journal Article
Divisions: Faculty of Science > Computer Science
Journal or Publication Title: Trends in Molecular Medicine
Publisher: Elsevier Ltd. * Trends Journals
ISSN: 1471-4914
Official Date: 2012
Dates:
DateEvent
2012Published
Volume: Vol.18
Number: No.12
Page Range: pp. 723-731
DOI: 10.1016/j.molmed.2012.10.003
Status: Peer Reviewed
Publication Status: Published

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us