Barber, T. M. and Franks, S. (2012) Adipocyte biology in polycystic ovary syndrome. Molecular and Cellular Endocrinology, Volume 373 (Number 1-2). pp. 68-76. doi:10.1016/j.mce.2012.10.010

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Abstract

Polycystic Ovary Syndrome (PCOS) is a common endocrinopathy that is associated with an adverse metabolic profile including insulin resistance. There is a clear association between obesity, the development of PCOS and the severity of its phenotypic, biochemical and metabolic features. Evidence to support this link includes data from epidemiological, pathophysiological and genetic studies. Given the importance of obesity in the development and manifestation of PCOS, ongoing research into the many facets of adipocyte biology in women with the condition is important and should continue to be a priority. In this review article, we discuss the existing literature on fat distribution, adipokines, adipocyte hypertrophy and adipocyte steroid metabolism in women with PCOS.

Item Type:	Submitted Journal Article
Divisions:	Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Molecular and Cellular Endocrinology
Publisher:	Elsevier
ISSN:	0303-7207
Official Date:	2012
Dates:	Date Event 2012 Published
Volume:	Volume 373
Number:	Number 1-2
Page Range:	pp. 68-76
DOI:	10.1016/j.mce.2012.10.010
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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